Quercetin Absorption: Forms, Food & Timing, Compared
Bottom line
B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off.We found 359 studies with usable absorption data for this supplement, 56 of them in people; every value below is copied from its paper and cited.
Quercetin aglycone / dihydrate measured higher than rutin in the one human head-to-head study (grade B).
Quercetin aglycone / dihydrate is the best-characterized form: 8 human studies (total n=71) with measured absorption values (absorption evidence grade B).
- Studies in database
- 359 (all full-text)
- Species
- 56 human, 8 pig, 204 rodent, 19 other animal, 72 in vitro
- Form comparison grades
- D: animal or lab data only, or conflicting comparisons. All grades are drafts pending reviewer sign-off. Isoquercetin / EMIQ (quercetin-3-glucoside) vs Quercetin aglycone / dihydrateB: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off. Rutin vs Quercetin aglycone / dihydrate
Educational information about published research; not medical advice. Not intended to diagnose, treat, cure or prevent any disease. Talk to a clinician before changing supplements, especially if pregnant, nursing or on medication.
Best-absorbed form
Draft — pending reviewer- Best-absorbed form in our data: Quercetin aglycone / dihydrate (evidence grade B).
- Quercetin aglycone / dihydrate measured higher than rutin in the one human head-to-head study (grade B).
- Caveat: this rests on one small study, so treat it as provisional.
Absorption evidence only, from the graded comparisons on this page. Not a recommendation to buy any product, not dosing advice, not medical advice.
303 of 359 studies are not in humans; each is labeled with a species badge.
Quercetin forms compared
| Form | Lowest | Highest | Studies | PMIDs |
|---|---|---|---|---|
| Quercetin aglycone / dihydrate | 15.39 | 463 | 1 | 18241083 |
| Quercetin phytosome | 126.35 | 223.1 | 1 | 30328058 |
| Rutin | 142.7 | 142.7 | 1 | 12888197 |
n = number of human studies. Full values with doses, sources and citations are in the data tables below.
Form tags are matched automatically and need reviewer confirmation. Values are not normalized across studies.
Species (abstract screen): 16 human, 3 pig, 59 rodent, 11 other animal, 12 in vitro
101 studies (16 human) · show quotes
- Loading… Each study is also listed with its citation in Studies.
Quercetin isoquercetin / emiq (quercetin-3-glucoside) vs quercetin aglycone / dihydrate: which absorbs better?
No study in our database compares these two forms directly.
Species (abstract screen): no studies
No relevant studies in our database address this question yet. We don't fill gaps with guesses.
Quercetin quercetin phytosome vs quercetin aglycone / dihydrate: which absorbs better?
No study in our database compares these two forms directly.
Species (abstract screen): no studies
No relevant studies in our database address this question yet. We don't fill gaps with guesses.
Quercetin micellar (lipomicel) vs quercetin aglycone / dihydrate: which absorbs better?
No study in our database compares these two forms directly.
Species (abstract screen): no studies
No relevant studies in our database address this question yet. We don't fill gaps with guesses.
Quercetin rutin vs quercetin aglycone / dihydrate: which absorbs better?
Quercetin aglycone / dihydrate measured higher than rutin in the one human head-to-head study (grade B). See the measured values →
Species (abstract screen): no studies
No relevant studies in our database address this question yet. We don't fill gaps with guesses.
Should you take Quercetin with food?
B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off.human + animal datahow we gradeSpecies (abstract screen): 31 human, 2 pig, 15 rodent, 1 other animal, 1 in vitro
Grade basis (abstract screen): 20 human randomized/crossover studies; A-eligible only once the reviewer confirms they agree (capped at B until then). Auto-computed draft grade — pending reviewer review.
50 studies (31 human) · show quotes
- Loading… Each study is also listed with its citation in Studies.
Best time to take Quercetin
Not graded: no comparable evidence yet. All grades are drafts pending reviewer sign-off.no datahow we gradeSpecies (abstract screen): no studies
Grade basis (abstract screen): No relevant studies in the database for this question.
No relevant studies in our database address this question yet. We don't fill gaps with guesses.
Quercetin cost per mg calculator
Compare what you pay per mg of each form. Shows published ranges only; no dose recommendations.
FAQ
Which form of Quercetin is best absorbed?
Best-absorbed form in our data: Quercetin aglycone / dihydrate (evidence grade B). Quercetin aglycone / dihydrate measured higher than rutin in the one human head-to-head study (grade B). Caveat: this rests on one small study, so treat it as provisional. See the evidence →
Is Quercetin isoquercetin / emiq (quercetin-3-glucoside) better absorbed than quercetin aglycone / dihydrate?
We have no relevant studies in our database that mention both forms, but no graded head-to-head measurement yet. See the verbatim findings in this section. See the evidence →
Is Quercetin quercetin phytosome better absorbed than quercetin aglycone / dihydrate?
We have no relevant studies in our database that mention both forms, but no graded head-to-head measurement yet. See the verbatim findings in this section. See the evidence →
Is Quercetin micellar (lipomicel) better absorbed than quercetin aglycone / dihydrate?
We have no relevant studies in our database that mention both forms, but no graded head-to-head measurement yet. See the verbatim findings in this section. See the evidence →
Is Quercetin rutin better absorbed than quercetin aglycone / dihydrate?
Quercetin aglycone / dihydrate measured higher than rutin in the one human head-to-head study (grade B). See the evidence →
Should Quercetin be taken with food?
We have 50 relevant studies in our database that mention food or fasting. See the evidence →
When is the best time to take Quercetin?
We have no relevant studies in our database that mention timing. See the evidence →
Is this dosing advice?
No. We summarize published absorption research and compare prices. Talk to a clinician about what's right for you. See the evidence →
Answers summarize the data on this page.
Measured absorption data (full-text extraction)
534 papers read in full text, 359 with usable data (175 excluded as off-topic, reviews or off-target). 2892 values extracted. Species: Rodent 204In vitro 72Human 56Other animal 19Pig 8
Grades: draft — pending reviewer (Dr. Colin Reily). Directions are auto-parsed from author statements; values are copied exactly as printed, never converted or estimated.
Forms with measured values
| Form | Studies | Values | Absorption evidence grade | Species |
|---|---|---|---|---|
| Quercetin aglycone / dihydrate | 38 | 359 | B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off. 8 human studies, total n=71, 5 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | Rodent×15Human×11Other animal×8Pig×4 |
| Isoquercetin / EMIQ (quercetin-3-glucoside) | 14 | 82 | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 2 human studies, total n=14, 2 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | Rodent×9Human×2Other animal×2Pig×1 |
| Rutin | 19 | 147 | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 2 human studies, total n=12, 2 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | Rodent×10Other animal×5Human×3Pig×1 |
| Quercetin phytosome | 1 | 8 | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 1 human study, total n=12, 1 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | Human×1 |
| Micellar (LipoMicel) | 14 | 79 | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 2 human studies, total n=26, 2 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | Rodent×8Other animal×4Human×2 |
Single-form studies count as evidence for that form. Form tags are keyword-matched from arm descriptions and need reviewer confirmation.
Head-to-head comparisons
D: animal or lab data only, or conflicting comparisons. All grades are drafts pending reviewer sign-off.Isoquercetin / EMIQ (quercetin-3-glucoside) vs Quercetin aglycone / dihydratecombined head-to-head + matched single-form grade
head-to-head only; no matched single-form separation. H2H: D (no human head-to-head; 2 non-human studies); indirect: none
| Study | Comparison | Parameter | Author-stated result | p |
|---|---|---|---|---|
| Rodent PMID 12696973 | RG vs Q | AUC (quercetin) | RG-rutin > quercetin (about 4.5-fold) “approximately 4.5- and 2-fold higher” (Abstract; Results) | NR |
| Rodent PMID 12696973 | RG vs Q/RU | 24 h urinary excretion | RG-rutin highest “The highest 24 h urinary excretion was observed in RG-rutin-administered rats.” (Abstract) | NR |
| Other animal PMID 20230651 | isoquercitrin vs quercetin aglycone | Cmax1, Cmax2, AUCQuercetin, AUCIsorhamnetin, AUCTotal | isoquercitrin > quercetin “AUC values of quercetin, isorhamnetin and of total plasma flavonols were significantly higher after administration of isoquercitrin” (Table 2) | <0.001 (Cmax, AUC quercetin, AUC total); <0.01 (AUC isorhamnetin) |
Not graded: no comparable evidence yet. All grades are drafts pending reviewer sign-off.Quercetin phytosome vs Quercetin aglycone / dihydratecombined head-to-head + matched single-form grade
no comparable evidence. H2H: none (no direct comparison in extracted data); indirect: none
Not graded: no comparable evidence yet. All grades are drafts pending reviewer sign-off.Micellar (LipoMicel) vs Quercetin aglycone / dihydratecombined head-to-head + matched single-form grade
no comparable evidence. H2H: none (no direct comparison in extracted data); indirect: none
B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off.Rutin vs Quercetin aglycone / dihydratecombined head-to-head + matched single-form grade
head-to-head only; no matched single-form separation. H2H: B (1 human studies (1 randomized/crossover); majority: second form higher (1 agree, 0 contradict)); indirect: none
| Study | Comparison | Parameter | Author-stated result | p |
|---|---|---|---|---|
| Human PMID 11151743 | quercetin aglycone vs rutin, dose 1 (Q8 vs R16) | AUC0-24h | aglycone > rutin “statistically significantly different for the two treatments at dose 1 (P=0.0090)” (Results p.548) | 0.0090 |
| Human PMID 11151743 | quercetin aglycone vs rutin, dose 2 (Q20 vs R40) | AUC0-24h | aglycone > rutin “and at dose 2, (P=0.030), but not at dose 3” (Results p.548) | 0.030 |
| Human PMID 11151743 | quercetin aglycone vs rutin, dose 3 (Q50 vs R100) | AUC0-24h | no significant difference “but not at dose 3” (Results p.548) | no |
| Human PMID 11151743 | quercetin aglycone vs rutin, dose 1 | Cmax | aglycone > rutin “statistically significantly different ... at dose 1 (P=0.0025), but not at the two largest doses” (Results p.549) | 0.0025 |
| Human PMID 11151743 | quercetin aglycone vs rutin, doses 2 and 3 | Cmax | no significant difference “but not at the two largest doses” (Results p.549) | no |
| Human PMID 11151743 | quercetin aglycone vs rutin, doses 1, 2, 3 | tmax | aglycone shorter than rutin “The differences were statistically significant at all doses (P=0.0019, P=0.0050 and P=0.0098 for doses 1, 2 and 3, respectively)” (Results p.549) | 0.0019; 0.0050; 0.0098 |
| Rodent PMID 11216481 | rutin vs quercetin aglycone (4 h) | plasma total quercetin metabolites | rutin lower (2.8 vs 11.7 µM) “binding of a glucose-rhamnose ... markedly decreases it” (Results p.172) | NR |
| Rodent PMID 12696973 | RG vs Q | AUC (quercetin) | RG-rutin > quercetin (about 4.5-fold) “approximately 4.5- and 2-fold higher” (Abstract; Results) | NR |
| Rodent PMID 12696973 | RG vs Q/RU | 24 h urinary excretion | RG-rutin highest “The highest 24 h urinary excretion was observed in RG-rutin-administered rats.” (Abstract) | NR |
| Pig PMID 12949368 | E1-R vs E1-Q and E1-Q3G | AUC total | rutin < quercetin, Q3G “total bioavailability from the glucorhamnoside was significantly lower than that from quercetin or from Q3G” (Table 1) | <0.05 |
| Other animal PMID 22916908 | R50 vs Q50 | Cmax | rutin > quercetin aglycone “Means in a row without a common letter differ significantly, P < 0.05.” (Table 1) | <0.05 |
| Other animal PMID 22916908 | R50 vs Q50 | AUCTotal | rutin > quercetin aglycone “Means in a row without a common letter differ significantly, P < 0.05.” (Table 1) | <0.05 |
| Other animal PMID 22916908 | R50 vs Q50 | Tmax | no difference “tmax, min 30.0 ± 0.0a 42.0 ± 7.3a” (Table 1) | NR (same letter) |
| Other animal PMID 25795488 | QA vs RU d 2 | AUC quercetin | QA > RU “AUC of quercetin and isorhamnetin was greater (P < 0.05) ... in QA- than in RU-fed calves” (Results; Table 2) | <0.05 |
| Other animal PMID 25795488 | QA vs RU d 2 | AUC total flavonols | QA tended to be greater “tended to be greater for total flavonols (P < 0.1)” (Results) | <0.1 |
| Other animal PMID 25795488 | QA vs RU d 2 | Tmax isorhamnetin | RU later than QA on both days “Tmax was greater (P < 0.05) in RU- than in QA-fed calves on both days” (Results; Table 2) | <0.05 |
| Other animal PMID 30207714 | R and OB vs Q and OS | AUC of total flavonols | R, OB > Q, OS “Bioavailability of quercetin calculated as the AUC of total plasma flavonols was significantly higher after rutin and OB extract compared to the aglycone and OS extract” (Fig. 1 inset; Results) | <0.05 (different letters) |
| Other animal PMID 30207714 | R vs Q | Cmax and AUC of total flavonols | R about 10x Cmax and 3-4x AUC vs Q (authors' approximation) “approximately 10 times higher maximum total flavonol plasma concentrations and an 3-4 times greater AUC” (Discussion p.10190) | NR |
Cmax, Tmax and AUC by study arm (2657 values)
| Study | Arm / form | Dose | Fed | n | Analyte | Param | Value | Units | Source |
|---|---|---|---|---|---|---|---|---|---|
| Human 10099940 | fried onions (Sainsbury's extra large, class II); quercetin glucosides | 50.4 mg quercetin aglycone (225 g onions) (elemental) | after overnight fast | 5 | quercetin (total, after acid hydrolysis) (plasma) | Cmax peak at 2 h | 248.4 ± 103.9 (SD) | ng/ml | Results p.93 para 1; Abstract |
| Human 10099940 | fried onions (Sainsbury's extra large, class II); quercetin glucosides | 50.4 mg quercetin aglycone (225 g onions) (elemental) | after overnight fast | 5 | quercetin (total, after acid hydrolysis) (plasma) | Cmax peak plasma quercetin, molar units | 0.73 ± 0.30 (SD) | µM | Discussion p.95 para 1 |
| Human 10099940 | fried onions (Sainsbury's extra large, class II); quercetin glucosides | 50.4 mg quercetin aglycone (225 g onions) (elemental) | after overnight fast | 5 | quercetin (total, after acid hydrolysis) (plasma) | Tmax | 2 | h | Results p.93; Abstract |
| Human 10801919 | pure quercetin-3-glucoside (Extrasynthese #011095) (Extrasynthese) | 325 µmol (151 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | Cmax peak concentration | 5.0 ± 1.0 (SEM) | µmol/L | Table 1; Abstract |
| Human 10801919 | pure quercetin-3-glucoside (Extrasynthese #011095) (Extrasynthese) | 325 µmol (151 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | Tmax time to reach peak concentration | 37 ± 12 (SEM) | min | Table 1; Abstract |
| Human 10801919 | pure quercetin-3-glucoside (Extrasynthese #011095) (Extrasynthese) | 325 µmol (151 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | AUC AUC0-72h (printed AUC0–72h) | 19.1 ± 2.9 (SEM) | h × µmol/L | Table 1 |
| Human 10801919 | pure quercetin-3-glucoside (Extrasynthese #011095) (Extrasynthese) | 325 µmol (151 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | AUC AUC0-72h | 5775 ± 876 (SEM) | h × ng/mL | Table 1 |
| Human 10801919 | pure quercetin-4'-glucoside (Carl Roth #4564) (Carl Roth) | 331 µmol (154 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | Cmax peak concentration | 4.5 ± 0.7 (SEM) | µmol/L | Table 1; Abstract |
| Human 10801919 | pure quercetin-4'-glucoside (Carl Roth #4564) (Carl Roth) | 331 µmol (154 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | Tmax time to reach peak concentration | 27 ± 5 (SEM) | min | Table 1; Abstract |
| Human 10801919 | pure quercetin-4'-glucoside (Carl Roth #4564) (Carl Roth) | 331 µmol (154 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | AUC AUC0-72h (printed AUC0–72h) | 17.5 ± 2.4 (SEM) | h × µmol/L | Table 1 |
| Human 10801919 | pure quercetin-4'-glucoside (Carl Roth #4564) (Carl Roth) | 331 µmol (154 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | total quercetin (aglycone after acid hydrolysis) (plasma) | AUC AUC0-72h | 5276 ± 730 (SEM) | h × ng/mL | Table 1 |
| Human 10801919 | pure quercetin-3-glucoside (Extrasynthese #011095) (Extrasynthese) | 325 µmol (151 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | isorhamnetin (after hydrolysis) (plasma) | Tmax time to peak isorhamnetin | 51 ± 19 (SEM) | min | Results p.1202 col 2 |
| Human 10801919 | pure quercetin-4'-glucoside (Carl Roth #4564) (Carl Roth) | 331 µmol (154 mg) µmol (salt/compound) | overnight fast; water only for 3 h; 2 g NaCl just before | 9 | isorhamnetin (after hydrolysis) (plasma) | Tmax time to peak isorhamnetin | 32 ± 5 (SEM) | min | Results p.1202 col 2 |
| Human 11151743 | quercetin aglycone capsule | 8 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h | 527 | µg hr/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 8 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-32h | 630 | µg hr/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 8 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Cmax | 41.4 | µg/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 8 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Tmax | 1.9 ± 1.2 (SD) | h | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 20 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h | 882 | µg hr/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 20 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-32h | 1058 | µg hr/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 20 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Cmax | 66.1 | µg/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 20 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Tmax | 2.7 ± 1.9 (SD) | h | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 50 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h | 1138 | µg hr/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 50 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-32h | 1323 | µg hr/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 50 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Cmax | 86.1 | µg/l | Table 1 |
| Human 11151743 | quercetin aglycone capsule | 50 mg (active compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Tmax | 4.9 ± 2.1 (SD) | h | Table 1 |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h | 381 | µg hr/l | Table 1 |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-32h | 479 | µg hr/l | Table 1 |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Cmax | 23.5 | µg/l | Table 1 |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Tmax | 6.5 ± 1.8 (SD) | h | Table 1 |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h | 636 | µg hr/l | Table 1 |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-32h | 793 | µg hr/l | Table 1 |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Cmax | 47.6 | µg/l | Table 1 |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Tmax | 7.4 ± 2.2 (SD) | h | Table 1 |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h | 1017 | µg hr/l | Table 1 |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-32h | 1202 | µg hr/l | Table 1 |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Cmax | 89.9 | µg/l | Table 1 |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | Tmax | 7.5 ± 2.2 (SD) | h | Table 1 |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (females) (plasma) | AUC AUC0-24h, females | 513 | µg h/l | Results p.549 (Gender differences) quote mismatch, check |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (males) (plasma) | AUC AUC0-24h, males | 295 | µg h/l | Results p.549 (Gender differences) |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (females) (plasma) | AUC AUC0-24h, females | 863 | µg h/l | Results p.549 (Gender differences) |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (males) (plasma) | AUC AUC0-24h, males | 525 | µg h/l | Results p.549 (Gender differences) |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (females) (plasma) | AUC AUC0-24h, females | 1946 | µg h/l | Results p.549 (Gender differences) |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (males) (plasma) | AUC AUC0-24h, males | 678 | µg h/l | Results p.549 (Gender differences) |
| Human 11151743 | rutin capsule | 16 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h gender difference (females vs males), p value only | NR | Results p.549 quote mismatch, check | |
| Human 11151743 | rutin capsule | 40 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h gender difference (females vs males), p value only | NR | Results p.549 quote mismatch, check | |
| Human 11151743 | rutin capsule | 100 mg (salt/compound) | overnight fast; water 200 ml at 2 h; lunch at 4 h, snacks at 6 and 10 h, dinner 8 h | 16 randomised, 12 completed | total plasma quercetin (after glucuronidase/sulfatase hydrolysis) (plasma) | AUC AUC0-24h gender difference (females vs males), p value only | NR | Results p.549 quote mismatch, check | |
| Human 11300332 | QC12 prodrug dissolved in 40 ml normal saline | 400 (equivalent to 298 mg quercetin; approx. 175 mg/m2 quercetin per Discussion) mg QC12 (salt/compound) | NR | 6 | QC12 (3'-(N-carboxymethyl)carbamoyl-3,4',5,7-tetrahydroxyflavone; quercetin prodrug) (plasma) | AUC AUC (plasma, QC12) | 56.97 | µM hour | Table I |
| Human 11300332 | QC12 prodrug dissolved in 40 ml normal saline | 400 (equivalent to 298 mg quercetin; approx. 175 mg/m2 quercetin per Discussion) mg QC12 (salt/compound) | NR | 6 | quercetin (released from QC12) (plasma) | AUC AUC (plasma, quercetin released) | 16.46 | µM·hour | Table I |
| Human 11300332 | QC12 prodrug dissolved in 40 ml normal saline | 400 (equivalent to 298 mg quercetin; approx. 175 mg/m2 quercetin per Discussion) mg QC12 (salt/compound) | NR | 6 | QC12 (3'-(N-carboxymethyl)carbamoyl-3,4',5,7-tetrahydroxyflavone; quercetin prodrug) (plasma) | AUC AUC | 44.54 ± 13.00 (SD) | µM hour | Table I |
| Human 11300332 | QC12 prodrug dissolved in 40 ml normal saline | 400 (equivalent to 298 mg quercetin; approx. 175 mg/m2 quercetin per Discussion) mg QC12 (salt/compound) | NR | 6 | quercetin (released from QC12) (plasma) | AUC AUC | 8.24 ± 6.81 (SD) | µM·hour | Table I |
| Human 11300332 | QC12 prodrug dissolved in 40 ml normal saline | 400 (equivalent to 298 mg quercetin; approx. 175 mg/m2 quercetin per Discussion) mg QC12 (salt/compound) | NR | 6 | QC12 (3'-(N-carboxymethyl)carbamoyl-3,4',5,7-tetrahydroxyflavone; quercetin prodrug) (plasma) | Cmax peak plasma QC12 after IV | 108.7 ± 41.67 (NR) | µM | Abstract (Summary) |
| Human 11300332 | QC12 prodrug dissolved in 40 ml normal saline | 400 (equivalent to 298 mg quercetin; approx. 175 mg/m2 quercetin per Discussion) mg QC12 (salt/compound) | NR | 6 | quercetin (released from QC12) (plasma) | Cmax peak plasma quercetin after IV QC12 | 19.9 ± 11.8 (NR) | µM | Abstract (Summary) |
| Human 11361045 | 160 g stewed homogenized onions (quercetin glucosides, mainly quercetin-3,4'-O-diglucoside and quercetin-4'-O-glucoside) | 100 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Cmax | 2.31 ± 1.46 (SD) | µg•mL–1 | Table I |
| Human 11361045 | isolated from onions, in 0.5% HPMC gel with 15% ethanol | 100 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Cmax | 2.12 ± 1.63 (SD) | µg•mL–1 | Table I |
| Human 11361045 | buckwheat tea powder providing quercetin rutinoside, in HPMC gel | 200 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Cmax | 0.64 ± 0.67 (SD) | µg•mL–1 | Table I |
| Human 11361045 | ground Rutinion forte tablets in HPMC gel | 200 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Cmax | 0.32 ± 0.34 (SD) | µg•mL–1 | Table I |
| Human 11361045 | 160 g stewed homogenized onions (quercetin glucosides, mainly quercetin-3,4'-O-diglucoside and quercetin-4'-O-glucoside) | 100 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Tmax | 0.68 ± 0.22 (SD) | h | Table I |
| Human 11361045 | isolated from onions, in 0.5% HPMC gel with 15% ethanol | 100 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Tmax | 0.70 ± 0.31 (SD) | h | Table I |
| Human 11361045 | buckwheat tea powder providing quercetin rutinoside, in HPMC gel | 200 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Tmax | 4.32 ± 1.83 (SD) | h | Table I |
| Human 11361045 | ground Rutinion forte tablets in HPMC gel | 200 mg quercetin equivalent (elemental) | water only first 2 h | 12 | total quercetin (after hydrolysis of conjugates) (plasma) | Tmax | 6.98 ± 2.94 (SD) | h | Table I |
Showing 60 of 2657 Cmax/Tmax/AUC values (human first). All 2892 values are in /api/supplements/quercetin.
References for this section (12)
- Human McAnlis GT, McEneny J, Pearce J, Young IS. Absorption and antioxidant effects of quercetin from onions, in man. European journal of clinical nutrition. 1999;53(2):92-6. PMID 10099940. doi:10.1038/sj.ejcn.1600682 PubMed · DOI · single-arm, single-meal, n=5
- Human Olthof MR, Hollman PC, Vree TB, Katan MB. Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans. The Journal of nutrition. 2000;130(5):1200-3. PMID 10801919. doi:10.1093/jn/130.5.1200 PubMed · DOI · randomized crossover, n=9
- Human Erlund I, Kosonen T, Alfthan G, Mäenpää J, Perttunen K, Kenraali J, Parantainen J, Aro A. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. European journal of clinical pharmacology. 2000;56(8):545-53. PMID 11151743. doi:10.1007/s002280000197 PubMed · DOI · randomized, double-blind, two-period crossover (diet-controlled), ascending doses within period, n=16 randomised; 12 completed
- Human Mulholland PJ, Ferry DR, Anderson D, Hussain SA, Young AM, Cook JE, Hodgkin E, Seymour LW, Kerr DJ. Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Annals of oncology : official journal of the European Society for Medical Oncology. 2001;12(2):245-8. PMID 11300332. doi:10.1023/a:1008372017097 PubMed · DOI · open-label, single-arm, sequential oral then IV, n=6
- Human Graefe EU, Wittig J, Mueller S, Riethling AK, Uehleke B, Drewelow B, Pforte H, Jacobasch G, Derendorf H, Veit M. Pharmacokinetics and bioavailability of quercetin glycosides in humans. Journal of clinical pharmacology. 2001;41(5):492-9. PMID 11361045. doi:10.1177/00912700122010366 PubMed · DOI · randomized four-way crossover, n=12
- Rodent Shimoi K, Yoshizumi K, Kido T, Usui Y, Yumoto T. Absorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats. Journal of agricultural and food chemistry. 2003;51(9):2785-9. PMID 12696973. doi:10.1021/jf026108a PubMed · DOI · parallel (four groups), n=16
- Other animal Reinboth M, Wolffram S, Abraham G, Ungemach FR, Cermak R. Oral bioavailability of quercetin from different quercetin glycosides in dogs. The British journal of nutrition. 2010;104(2):198-203. PMID 20230651. doi:10.1017/S000711451000053X PubMed · DOI · randomized crossover (Latin square for oral forms; oral vs i.v. crossover), n=9 (7 evaluated glycoside comparison; 8 absolute bioavailability)
- Rodent Morand C, Manach C, Crespy V, Remesy C. Respective bioavailability of quercetin aglycone and its glycosides in a rat model. BioFactors (Oxford, England). 2000;12(1-4):169-74. PMID 11216481. doi:10.1002/biof.5520120127 PubMed · DOI · parallel groups, single experimental meal; two experiments, n=24 (Exp 1) and 40 (Exp 2)
- Pig Cermak R, Landgraf S, Wolffram S. The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. The Journal of nutrition. 2003;133(9):2802-7. PMID 12949368. doi:10.1093/jn/133.9.2802 PubMed · DOI · randomized? NR; sequential crossover-style single-dose tests with 1-day washout, n=Exp 1: 4 pigs; Exp 2: 6; Exp 3: 3
- Other animal Berger LM, Wein S, Blank R, Metges CC, Wolffram S. Bioavailability of the flavonol quercetin in cows after intraruminal application of quercetin aglycone and rutin. Journal of dairy science. 2012;95(9):5047-5055. PMID 22916908. doi:10.3168/jds.2012-5439 PubMed · DOI · randomized crossover? (printed: crossover design with 2-d wash-out); i.v. trial in 2 animals, n=5
- Other animal Maciej J, Schäff CT, Kanitz E, Tuchscherer A, Bruckmaier RM, Wolffram S, Hammon HM. Bioavailability of the flavonol quercetin in neonatal calves after oral administration of quercetin aglycone or rutin. Journal of dairy science. 2015;98(6):3906-17. PMID 25795488. doi:10.3168/jds.2015-9361 PubMed · DOI · parallel (3 groups, repeated study on d 2 and d 29), n=21
- Other animal Wein S, Beyer B, Zimmermann BF, Blank RH, Wolffram S. Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. Journal of agricultural and food chemistry. 2018;66(39):10188-10192. PMID 30207714. doi:10.1021/acs.jafc.8b03049 PubMed · DOI · randomized crossover, n=3
Indirect comparisons (across studies)
Each form's values come from different human studies that tested one form only. Rows are compared only when parameter, analyte, matrix, fed/fasted state, single vs repeated dosing, AUC interval and units all match, and baseline correction matches where reported (a value with baseline correction not reported is labeled and capped at grade D). Serum and plasma are treated as the same matrix. Ranges are the lowest and highest printed values; nothing is averaged or pooled. Conditions a paper does not state are recorded as NR and never matched.
Indirect comparison: weighs less than head-to-head evidence; comparisons using values with baseline correction not reported are capped at C. The combined grade for named pairs is shown in the head-to-head section. draft — pending reviewer (Dr. Colin Reily).
Indirect comparisonQuercetin aglycone / dihydrate vs RutinNot graded: no comparable evidence yet. All grades are drafts pending reviewer sign-off.baseline correction not reportedHead-to-head grade: B (takes precedence)
only Tmax (timing) ranges separate; Tmax is shown but not graded. Head-to-head evidence exists and takes precedence over this indirect comparison.
| Matched conditions | Quercetin aglycone / dihydrate: range (studies, n) | Rutin: range (studies, n) | Ranges | PMIDs |
|---|---|---|---|---|
| Human Tmax, total quercetin, serum/plasma, fed, single dose, baseline-corrected: not reported baseline correction not reported (grade capped at C) values as printed (doses not normalized) | 2.3–4.7 h 1 study, n=6 4.7 @ 500 mg (PMID 23094941); 2.3 @ 500 mg (PMID 23094941); 3.3 @ 500 mg (PMID 23094941) | 6.98 h 1 study, n=12 6.98 @ 200 mg quercetin equivalent (PMID 11361045) | do not overlap; Quercetin aglycone / dihydrate faster | 1136104523094941 |
Pairs that cannot be compared indirectly yet
- Quercetin aglycone / dihydrate vs Isoquercetin / EMIQ (quercetin-3-glucoside): no matched condition set: arms differ on units
- Quercetin aglycone / dihydrate vs Quercetin phytosome: no matched condition set: arms differ on fed state
- Quercetin aglycone / dihydrate vs Micellar (LipoMicel): matched only within the same study
- Isoquercetin / EMIQ (quercetin-3-glucoside) vs Rutin: no matched condition set: arms differ on fed state
- Isoquercetin / EMIQ (quercetin-3-glucoside) vs Quercetin phytosome: no matched condition set: arms differ on analyte
- Isoquercetin / EMIQ (quercetin-3-glucoside) vs Micellar (LipoMicel): no matched condition set: arms differ on units
- Rutin vs Quercetin phytosome: no matched condition set: arms differ on analyte
- Rutin vs Micellar (LipoMicel): no matched condition set: arms differ on fed state
- Quercetin phytosome vs Micellar (LipoMicel): no matched condition set: arms differ on analyte
How this table was built
Indirect (cross-study) PK comparisons from bundle_v2 single-form human arms. Values are copied as printed. Matching key: parameter, analyte, matrix, fed/fasted, single vs repeated, AUC interval (from parameter_detail), baseline correction, units (exact). No pooling/averaging: per-form ranges are min–max of printed values. Analyte for minerals/B12 is classed as total element vs isotope/radiotracer; units compared after removing spaces/separators only; IV arms excluded; serum and plasma treated as the same matrix; curated magnesium v1 rows (mapped from stated conditions only, NR otherwise, deduped against the bundle) are included; baseline correction NR is treated as unknown (may match corrected or uncorrected sets; labeled and capped at C); for % absorption endpoints an unreported baseline correction is treated as not applicable. Normalization: value / elemental dose (mg) ONLY when dose_basis is 'elemental', dose unit is mg, single dose, baseline-corrected=yes, parameter Cmax/AUC. Grade capped at C. Run after merge_bundle.py.
Evidence grades
Rubric v2: single-form human studies count. Hover or focus a grade for what it means; see the methodology. All grades are drafts pending reviewer sign-off.
| Question | Grade & basis | Species |
|---|---|---|
| Page grade (best of the grades below) | B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off. | rubric v2, draft |
| Quercetin aglycone / dihydrate: absorption evidence | B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off. 8 human studies, total n=71, 5 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | human |
| Isoquercetin / EMIQ (quercetin-3-glucoside): absorption evidence | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 2 human studies, total n=14, 2 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | human |
| Rutin: absorption evidence | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 2 human studies, total n=12, 2 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | human |
| Quercetin phytosome: absorption evidence | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 1 human study, total n=12, 1 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | human |
| Micellar (LipoMicel): absorption evidence | C: limited or conflicting human data: 1–2 studies, head-to-head and single-form evidence disagree, or baseline correction not reported. All grades are drafts pending reviewer sign-off. 2 human studies, total n=26, 2 randomized/crossover; consistency not evaluable (no matched set with ≥2 studies) | human |
| Isoquercetin / EMIQ (quercetin-3-glucoside) vs Quercetin aglycone / dihydrate | D: animal or lab data only, or conflicting comparisons. All grades are drafts pending reviewer sign-off. head-to-head only; no matched single-form separation. H2H: D (no human head-to-head; 2 non-human studies); indirect: none | human (head-to-head + matched single-form) |
| Rutin vs Quercetin aglycone / dihydrate | B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off. head-to-head only; no matched single-form separation. H2H: B (1 human studies (1 randomized/crossover); majority: second form higher (1 agree, 0 contradict)); indirect: none | human (head-to-head + matched single-form) |
| With food (abstract screen) | B: solid human data. Forms: 3+ human studies. Comparisons: one randomized head-to-head, or matched single-form evidence from 2+ studies per form. All grades are drafts pending reviewer sign-off.human + animal datahow we grade 20 human randomized/crossover studies; A-eligible only once the reviewer confirms they agree (capped at B until then). Auto-computed draft grade — pending reviewer review. | 31 human, 2 pig, 15 rodent, 1 other animal, 1 in vitro |
| Best time (abstract screen) | Not graded: no comparable evidence yet. All grades are drafts pending reviewer sign-off.no datahow we grade No relevant studies in the database for this question. | no studies |
Studies (359)
Sorted human → primate → pig → rodent → other animal → in vitro. Quotes are verbatim from the abstract or free full text. Paywalled papers: abstract only.
Show all 359 studies and quotes
- HumanValidation of a quantitation method for conjugated quercetin in human plasma.Journal of pharmaceutical and biomedical analysis, 2025 · Design: randomized crossover · n: 16 · full text (PDF extraction) · open access: noPMID 39961223DOI 10.1016/j.jpba.2025.116738Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanMicrobiological and Pharmacokinetic Aspects of a Water-Soluble Quercetin 3-O-rutinoside, EubioQuercetin: A Direct Comparison With Quercetin in In Vitro and Human Clinical Studies.Journal of food science, 2025 · Design: randomized crossover · n: 16 randomized (Fig. 2a); 15 participants stated in Results/Fig. 7 · full text (PDF extraction) · open access: noPMID 41014182DOI 10.1111/1750-3841.70579Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- HumanEnzymatically modified isoquercitrin in soy protein temporarily enhanced the plasma amino-acid concentrations, antioxidant index, and plasma hormone levels: a randomized, double-blind cross-over trial.Amino acids, 2023 · Design: randomized crossover · n: 9 analysed (16 enrolled) · full text (PDF extraction) · open access: noPMID 37154870DOI 10.1007/s00726-023-03267-4Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- HumanA Pharmacokinetic Study of Different Quercetin Formulations in Healthy Participants: A Diet-Controlled, Crossover, Single- and Multiple-Dose Pilot Study.Evidence-based complementary and alternative medicine : eCAM, 2023 · Design: open-label crossover (randomization NR), single- and multiple-dose pilot · n: 10 · full text (PDF extraction) · open access: yesPMID 37600550DOI 10.1155/2023/9727539 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- HumanLowering effect of combined sweet potato and onion intake on plasma quercetin concentration and underlying mechanism involving intestinal β-glucosidase activity.Bioscience, biotechnology, and biochemistry, 2022 · Design: other (human test-meal study; crossover status NR; plus in vitro rat intestinal beta-glucosidase experiment) · n: 6 · full text (PDF extraction) · open access: noPMID 36102655DOI 10.1093/bbb/zbac155Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- HumanEnhanced Bioavailability and Pharmacokinetics of a Natural Self-Emulsifying Reversible Hybrid-Hydrogel System of Quercetin: A Randomized Double-Blinded Comparative Crossover Study.ACS omega, 2022 · Design: randomized crossover · n: 16 · full text (PDF extraction) · open access: yesPMID 36570285DOI 10.1021/acsomega.2c05929 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- HumanFood frequency questionnaire is a valid assessment tool of quercetin and kaempferol intake in Iranian breast cancer patients according to plasma biomarkers.Nutrition research (New York, N.Y.), 2021 · Design: observational (consecutive case series; FFQ validation against plasma biomarkers) · n: 140 · full text (PDF extraction) · open access: noPMID 34311274DOI 10.1016/j.nutres.2021.06.004Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanProspective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.Food & function, 2020 · Design: RCT · n: 31 · full text (PDF extraction) · open access: yes (free in PMC)PMID 32347270DOI 10.1039/d0fo00565g (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- HumanImproved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin.European journal of drug metabolism and pharmacokinetics, 2019 · Design: randomized crossover · n: 12 · full text (PDF extraction) · open access: yesPMID 30328058DOI 10.1007/s13318-018-0517-3 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- HumanEvaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers.Phytotherapy research : PTR, 2018 · Design: open-label, 2-period, single-sequence (control then quercetin phase) · n: 12 · full text (PDF extraction) · open access: noPMID 29168292DOI 10.1002/ptr.5978Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanComparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from in vitro models and a human bioavailability study.Journal of functional foods, 2018 · Design: randomized crossover (un-blinded) human study, plus in vitro digestion and Caco-2 experiments · n: 21 randomised; 19 completed per protocol · full text (PDF extraction) · open access: yesPMID 30344649DOI 10.1016/j.jff.2018.07.035 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- HumanHigher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans.European journal of nutrition, 2017 · Design: randomized crossover (single-blind, diet-controlled) · n: 12 · full text (PDF extraction) · open access: noPMID 26482244DOI 10.1007/s00394-015-1084-xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- HumanNo effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight-to-obese patients with (pre-)hypertension: a randomized double-blinded, placebo-controlled crossover trial.European journal of nutrition, 2017 · Design: randomized crossover · n: 70 randomized; 68 analysed · full text (PDF extraction) · open access: noPMID 27423432DOI 10.1007/s00394-016-1267-0Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanQuercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial.The British journal of nutrition, 2016 · Design: randomized crossover · n: 22 analysed (23 randomised, 1 withdrawn) · full text (PDF extraction) · open access: noPMID 26785820DOI 10.1017/S0007114515005310Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanAcute effects of quercetin-3-O-glucoside on endothelial function and blood pressure: a randomized dose-response study.The American journal of clinical nutrition, 2016 · Design: randomized crossover · n: 15 · full text (PDF extraction) · open access: noPMID 27169837DOI 10.3945/ajcn.116.131268Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanBioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources.Food research international (Ottawa, Ont.), 2016 · Design: randomized crossover · n: 6 · full text (PDF extraction) · open access: noPMID 28847395DOI 10.1016/j.foodres.2016.02.013Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- HumanComparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: a randomized, single-blinded, cross-over study.Food & function, 2015 · Design: randomized crossover (single-blind, two-period, two-sequence) · n: 6 · full text (PDF extraction) · open access: noPMID 25832541DOI 10.1039/c5fo00155bVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- HumanSimultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects.The British journal of nutrition, 2015 · Design: randomized crossover (Expt I); fixed-order within-subject (Expts II, III) · n: 19 (Expt I); 6 (Expt II); 6 (Expt III) · full text (PDF extraction) · open access: noPMID 25865751DOI 10.1017/S0007114515000537Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- HumanEffect of Processed Onions on the Plasma Concentration of Quercetin in Rats and Humans.Journal of food science, 2015 · Design: parallel groups in rats (n=5 per group); human comparison of two onion peel products · full text (PDF extraction) · open access: noPMID 26375490DOI 10.1111/1750-3841.13079Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- HumanExposure of breastfed infants to quercetin after consumption of a single meal rich in quercetin by their mothers.Molecular nutrition & food research, 2014 · Design: open-label · n: 11 · full text (PDF extraction) · open access: noPMID 23963751DOI 10.1002/mnfr.201200773Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- HumanQuercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C (-2964G>A) and *1F (734C>A) gene polymorphisms.BioMed research international, 2014 · Design: randomized crossover (2 treatment phases, fixed order described: caffeine alone then quercetin pretreatment) · n: 12 · full text (PDF extraction) · open access: yesPMID 25025048DOI 10.1155/2014/405071 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanQuercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults.Nutrition (Burbank, Los Angeles County, Calif.), 2014 · Design: single-arm · n: 16 · full text (PDF extraction) · open access: noPMID 25280405DOI 10.1016/j.nut.2014.03.032Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanEffect of quercetin on CYP3A activity in Chinese healthy participants.Journal of clinical pharmacology, 2012 · Design: randomized crossover (open, 2-period) · n: 18 · full text (PDF extraction) · open access: noPMID 21680781DOI 10.1177/0091270011406278Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanEnriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules.The British journal of nutrition, 2012 · Design: randomized crossover (single-blinded, diet-controlled pilot) · n: 6 · full text (PDF extraction) · open access: noPMID 21774840DOI 10.1017/S0007114511003242Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- HumanInhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.British journal of clinical pharmacology, 2012 · Design: randomized crossover (two-phase, placebo-controlled) · n: 16 · full text (PDF extraction) · open access: yes (free in PMC)PMID 22114872DOI 10.1111/j.1365-2125.2011.04150.x (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanPharmacokinetics of quercetin absorption from apples and onions in healthy humans.Journal of agricultural and food chemistry, 2012 · Design: randomized crossover · n: 16 completed (21 initially recruited) · full text (PDF extraction) · open access: noPMID 22439822DOI 10.1021/jf3001857Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- HumanUHPLC-(ESI)QTOF MS/MS profiling of quercetin metabolites in human plasma postconsumption of applesauce enriched with apple peel and onion.Journal of agricultural and food chemistry, 2012 · Design: randomized crossover · n: 16 · full text (PDF extraction) · open access: noPMID 22867437DOI 10.1021/jf302637tVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- HumanAcute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide.Nutrition research (New York, N.Y.), 2012 · Design: randomized, double-blind, placebo-controlled crossover (both groups) · n: 17 (5 normotensive + 12 hypertensive) · full text (PDF extraction) · open access: noPMID 22935338DOI 10.1016/j.nutres.2012.06.018Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanComparison of quercetin pharmacokinetics following oral supplementation in humans.Journal of food science, 2012 · Design: parallel (randomized to 1 of 3 carriers, 6 per group); single dose · n: 18 · full text (PDF extraction) · open access: noPMID 23094941DOI 10.1111/j.1750-3841.2012.02934.xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- HumanRelative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.European journal of clinical nutrition, 2010 · Design: single-arm · n: 10 · full text (PDF extraction) · open access: noPMID 20125185DOI 10.1038/ejcn.2010.6Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanSteady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects.Clinical pharmacokinetics, 2010 · Design: open-label, single-arm, within-subject control (two periods) · n: 8 · full text (PDF extraction) · open access: noPMID 20528005DOI 10.2165/11531820-000000000-00000Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- Humanalpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans.Archives of biochemistry and biophysics, 2010 · Design: randomized crossover (time-course: 5 volunteers; 'cross-over study'); second experiment 5 volunteers (3 male, 2 female) · n: 5 (time-course; 4 for rutin) and 5 (experiment 2); plasma metabolite profiling in 7 volunteers · full text (PDF extraction) · open access: noPMID 20638359DOI 10.1016/j.abb.2010.06.036Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanQuercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study.The British journal of nutrition, 2009 · Design: randomized crossover · n: 93 analysed (96 enrolled) · full text (PDF extraction) · open access: noPMID 19402938DOI 10.1017/S0007114509359127Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanQuercetin pharmacokinetics in humans.Biopharmaceutics & drug disposition, 2008 · Design: single-arm · n: 10 · full text (PDF extraction) · open access: noPMID 18241083DOI 10.1002/bdd.605Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanQuercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides.The Journal of nutrition, 2008 · Design: randomized crossover · n: 9 · full text (PDF extraction) · open access: noPMID 18424596DOI 10.1093/jn/138.5.885Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- HumanDaily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans.The Journal of nutrition, 2008 · Design: RCT · n: 35 (36 recruited and completed; 1 excluded retrospectively) · full text (PDF extraction) · open access: noPMID 18716159DOI 10.1093/jn/138.9.1615Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- HumanBioavailability of quercetin from berries and the diet.Nutrition and cancer, 2006 · Design: other (review of 3 interventions: partial crossover; randomized parallel; randomized parallel controlled diet) · n: Int.1: 20 selected (3 dropped out); Int.2: 40 (20+20) analysed for quercetin; Int.3: 80 recruited, 3 dropped (n=77) · full text (PDF extraction) · open access: noPMID 16800769DOI 10.1207/s15327914nc5401_3Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanAbsorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions.The British journal of nutrition, 2006 · Design: single-arm · n: 6 · full text (PDF extraction) · open access: noPMID 16869998DOI 10.1079/bjn20061809Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanEffect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults.Pharmacotherapy, 2006 · Design: open-label · n: 10 · full text (PDF extraction) · open access: noPMID 16945047DOI 10.1592/phco.26.9.1255Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanUrinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice.Journal of agricultural and food chemistry, 2004 · Design: single-arm · n: 3 humans; mice 5/10/15/20 · full text (PDF extraction) · open access: noPMID 14969553DOI 10.1021/jf030582eVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanConsumption of black currants, lingonberries and bilberries increases serum quercetin concentrations.European journal of clinical nutrition, 2003 · Design: randomized parallel dietary intervention · n: 40 (of 60 randomized into 3 groups; berry and control groups analysed) · full text (PDF extraction) · open access: noPMID 12548295DOI 10.1038/sj.ejcn.1601513Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanAbsorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.Drug metabolism and disposition: the biological fate of chemicals, 2003 · Design: other (in vivo regional jejunal perfusion, single-arm; separate control group) · n: 6 (perfusion); 5 (control) · full text (PDF extraction) · open access: noPMID 12756216DOI 10.1124/dmd.31.6.805Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- HumanEffects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers.Journal of the American College of Nutrition, 2003 · Design: randomized crossover (two 6-day dietary periods separated by 3 days) · n: 19 · full text (PDF extraction) · open access: noPMID 12805248DOI 10.1080/07315724.2003.10719296Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanHigh-performance liquid chromatographic determination of quercetin in human plasma and urine utilizing solid-phase extraction and ultraviolet detection.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003 · Design: single-arm (n=1 application of an HPLC assay) · n: 1 · full text (PDF extraction) · open access: noPMID 12888197DOI 10.1016/s1570-0232(03)00398-2Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanDisposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets.European journal of drug metabolism and pharmacokinetics, 2003 · Design: single-arm · n: 10 · full text (PDF extraction) · open access: noPMID 14527089DOI 10.1007/BF03190482Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanPlasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.European journal of clinical nutrition, 2002 · Design: randomized crossover (2-wk baseline, two 5-wk diet periods, 3-wk washout) · n: 37 · full text (PDF extraction) · open access: noPMID 12209378DOI 10.1038/sj.ejcn.1601409Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanPre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin.Annals of oncology : official journal of the European Society for Medical Oncology, 2001 · Design: open-label, single-arm, sequential oral then IV · n: 6 · full text (PDF extraction) · open access: noPMID 11300332DOI 10.1023/a:1008372017097Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- HumanPharmacokinetics and bioavailability of quercetin glycosides in humans.Journal of clinical pharmacology, 2001 · Design: randomized four-way crossover · n: 12 · full text (PDF extraction) · open access: noPMID 11361045DOI 10.1177/00912700122010366Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- HumanBioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans.The Journal of nutrition, 2000 · Design: randomized crossover · n: 9 · full text (PDF extraction) · open access: noPMID 10801919DOI 10.1093/jn/130.5.1200Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanQuercetin glucosides are completely hydrolyzed in ileostomy patients before absorption.The Journal of nutrition, 2000 · Design: single-arm, open-label · n: 4 · full text (PDF extraction) · open access: noPMID 11053503DOI 10.1093/jn/130.11.2658Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanPharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers.European journal of clinical pharmacology, 2000 · Design: randomized, double-blind, two-period crossover (diet-controlled), ascending doses within period · n: 16 randomised; 12 completed · full text (PDF extraction) · open access: noPMID 11151743DOI 10.1007/s002280000197Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- HumanAbsorption and antioxidant effects of quercetin from onions, in man.European journal of clinical nutrition, 1999 · Design: single-arm, single-meal · n: 5 · full text (PDF extraction) · open access: noPMID 10099940DOI 10.1038/sj.ejcn.1600682Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- HumanQuercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties.FEBS letters, 1998 · Design: single-arm · n: 10 · full text (PDF extraction) · open access: noPMID 9600261DOI 10.1016/s0014-5793(98)00367-6Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- HumanPlasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake.The American journal of clinical nutrition, 1998 · Design: randomized crossover · n: 15 · full text (PDF extraction) · open access: noPMID 9665097DOI 10.1093/ajcn/68.1.60Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- HumanAbsorption and disposition kinetics of the dietary antioxidant quercetin in man.Free radical biology & medicine, 1996 · Design: single-arm · n: 2 · full text (PDF extraction) · open access: noPMID 8891673DOI 10.1016/0891-5849(96)00129-3Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- HumanQuercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice.British journal of clinical pharmacology, 1993 · Design: randomized crossover · n: 8 · full text (PDF extraction) · open access: yes (free in PMC)PMID 12959295DOI 10.1111/j.1365-2125.1993.tb00396.x (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- PigEffect of dietary Achyranthes japonica extract on growth performance of growing pigs and absorption rate of quercetin in blood.Journal of animal science and technology, 2024 · Design: parallel (3 dose groups) · n: 9 · full text (PDF extraction) · open access: yesPMID 38618039DOI 10.5187/jast.2023.e23 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- PigConcomitant intake of quercetin with a grain-based diet acutely lowers postprandial plasma glucose and lipid concentrations in pigs.BioMed research international, 2014 · Design: randomized crossover (experiment 1, n=8); parallel randomized (experiment 2, 4 per group) · n: 16 (8 per experiment) · full text (PDF extraction) · open access: yesPMID 24847478DOI 10.1155/2014/748742 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- PigChronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration.Xenobiotica; the fate of foreign compounds in biological systems, 2012 · Design: randomized crossover (acute SA vs SA+Q, n=7) followed by single-group dietary pre-treatment arm (n=5) · n: 7 (first trial); 5 (pre-treatment trial) · full text (PDF extraction) · open access: noPMID 22188411DOI 10.3109/00498254.2011.641607Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- PigThe fatty acid pattern of dietary fat influences the oral bioavailability of the flavonol quercetin in pigs.The British journal of nutrition, 2006 · Design: randomized crossover · n: 6 pigs; 18 rats · full text (PDF extraction) · open access: noPMID 17181879DOI 10.1017/bjn20061953Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- PigLethal quercetin-digoxin interaction in pigs.Life sciences, 2004 · Design: randomized crossover · n: 6 pigs in 50 mg/kg experiment; 4 pigs in 40 mg/kg experiment · full text (PDF extraction) · open access: noPMID 14697403DOI 10.1016/j.lfs.2003.06.044Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- PigBioavailability of quercetin in pigs is influenced by the dietary fat content.The Journal of nutrition, 2004 · Design: randomized crossover? (consecutive experiments; randomization NR) · n: 7 · full text (PDF extraction) · open access: noPMID 15173420DOI 10.1093/jn/134.6.1508Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- PigThe bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors.The Journal of nutrition, 2003 · Design: randomized? NR; sequential crossover-style single-dose tests with 1-day washout · n: Exp 1: 4 pigs; Exp 2: 6; Exp 3: 3 · full text (PDF extraction) · open access: noPMID 12949368DOI 10.1093/jn/133.9.2802Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- PigBioavailability and metabolism of the flavonol quercetin in the pig.Free radical biology & medicine, 2000 · Design: sequential single-dose iv then oral in same animals (not randomized) · n: 4 · full text (PDF extraction) · open access: noPMID 10832067DOI 10.1016/s0891-5849(00)00195-7Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentpH-targeted and time-released microparticles of quercetin and lycopene for ulcerative colitis treatment: DoE-based formulation development, pharmacokinetics, and in-vivo proof of concept studies.Journal of drug targeting, 2026 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 40938667DOI 10.1080/1061186X.2025.2561211Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentIntranasal Delivery of Ligand-Conjugated NLCs Co-Loaded With Docetaxel and Quercetin: HPLC Method Development, Pharmacokinetics, and Brain Biodistribution in Wistar Rats for Glioblastoma.Biomedical chromatography : BMC, 2026 · Design: parallel · full text (PDF extraction) · open access: noPMID 41319703DOI 10.1002/bmc.70251Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentMicellar Co-Delivery of Fulvestrant and Quercetin to enhance oral Bioavailability: A potential Bioenhancement strategy.International journal of pharmaceutics, 2026 · Design: parallel · n: 15 · full text (PDF extraction) · open access: noPMID 41412433DOI 10.1016/j.ijpharm.2025.126512Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentQuercetin-loaded zeolitic imidazolate framework-8 nanoparticles through borneol-embedded hyaluronic acid hydrogel for ischemic stroke treatment.International journal of biological macromolecules, 2026 · Design: parallel · full text (PDF extraction) · open access: noPMID 41429389DOI 10.1016/j.ijbiomac.2025.149821Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentComparison of plasma and cecal quercetin in Enterococcus sp. rutin_18 mono-associated and germ-free mice fed rutin-supplemented diet.Bioscience of microbiota, food and health, 2026 · Design: parallel · n: 8 · full text (PDF extraction) · open access: yesPMID 41492379DOI 10.12938/bmfh.2025-021 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentDesign, optimization, and in vivo assessment of in situ pH-sensitive quercetin transbilosomes for the treatment of diabetes mellitus-associated heart failure.Journal of drug targeting, 2026 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 41579343DOI 10.1080/1061186X.2026.2621844Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentpH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy.Materials today. Bio, 2026 · Design: other (in vitro and in vivo preclinical formulation study) · full text (PDF extraction) · open access: yesPMID 41624536DOI 10.1016/j.mtbio.2026.102806 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentTwo-birds-one-stone, microfluidic producing DES/W microemulsions to solubilize quercetin and penetrate intestinal mucosa for enhanced oral bioavailability.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2026 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 41633432DOI 10.1016/j.ejpb.2026.115007Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentPunicic acid ethyl ester, a superior absorption-enhancer over pomegranate seed oil, dramatically improves quercetin bioavailability via strong interaction and rapid lipolysis.International journal of pharmaceutics: X, 2026 · Design: parallel · full text (PDF extraction) · open access: yesPMID 41675219DOI 10.1016/j.ijpx.2026.100499 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentIdentification of enzymatically modified isoquercitrin as a therapeutic lead for myotonic dystrophy type 1.NAR molecular medicine, 2026 · Design: other (preclinical efficacy study with tissue quercetin measurement) · full text (PDF extraction) · open access: yesPMID 41710065DOI 10.1093/narmme/ugag007 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentComparison of bioavailability of quercetin and its structural analogs in mice.Archives of biochemistry and biophysics, 2026 · Design: parallel · full text (PDF extraction) · open access: noPMID 41724417DOI 10.1016/j.abb.2026.110775Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentExcipient Nanoemulsion-Based Enhancement of Spinach (Spinacia oleracea) Quercetin Bioavailability and Antioxidant Efficacy: A Comprehensive In Vitro-In Vivo Evaluation of Gastrointestinal Fate.Journal of agricultural and food chemistry, 2026 · Design: parallel · n: 30 (four independent animal cohorts for different analyses) · full text (PDF extraction) · open access: noPMID 41771805DOI 10.1021/acs.jafc.5c11547Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentCrossing ocular barriers with quercetin-SPIONs: modulation of Bax/Bcl-2 balance in normal rat eyes.BMC pharmacology & toxicology, 2026 · Design: parallel (randomized groups) · n: 42 · full text (PDF extraction) · open access: yesPMID 41772653DOI 10.1186/s40360-026-01113-3 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentEngineered Novel Brijaluronic Terpesomes for Brain-Targeted Quercetin Delivery: Optimization, Ex Vivo and Radiokinetics.AAPS PharmSciTech, 2026 · Design: parallel · n: 45 · full text (PDF extraction) · open access: noPMID 41851521DOI 10.1208/s12249-026-03366-xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentInhalable quercetin dihydrate nanosuspension mitigates silica-induced pulmonary fibrosis in rats.Naunyn-Schmiedeberg's archives of pharmacology, 2026 · Design: parallel · n: 48 · full text (PDF extraction) · open access: noPMID 41854858DOI 10.1007/s00210-026-05180-5Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentEngineered Liposomal Quercetin Attenuates Myocardial Ischemia/Reperfusion Injury via Targeted HMGB1-NF-κB Suppression.Phytomedicine : international journal of phytotherapy and phytopharmacology, 2026 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 41931997DOI 10.1016/j.phymed.2026.158097Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentHepatoprotective Effects of Quercetin-Chitosan Nanoparticles on Nonalcoholic Fatty Liver Disease: In Vivo Study.Food science & nutrition, 2026 · Design: other (controlled animal efficacy study, 4 groups) · n: 24 · full text (PDF extraction) · open access: yesPMID 41971603DOI 10.1002/fsn3.71617 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentBrain-targeted mucoadhesive in situ gel incorporating quercetin-PEG conjugate and rivastigmine-loaded chitosan nanoparticles for Alzheimer's therapy.International journal of biological macromolecules, 2026 · Design: parallel (formulation comparison, intranasal; plus in vitro and ex vivo sheep nasal mucosa studies) · full text (PDF extraction) · open access: noPMID 41980692DOI 10.1016/j.ijbiomac.2026.151998Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentIon‑Responsive in situ Gel of Quercetin‑Loaded PEGylated Liposomes for Anti‑inflammatory Treatment of Dry Eye Disease.International journal of nanomedicine, 2026 · Design: other (preclinical parallel-group ocular PK, single topical instillation) · n: 63 rabbits (Methods p.6) · full text (PDF extraction) · open access: yesPMID 42338899DOI 10.2147/IJN.S603221 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentROS-Responsive Quercetin Nanoparticles Improve the Prognosis of Traumatic Brain Injury by Inhibiting Aberrant Nrf2-Keap1 Signaling Pathway Activation.Journal of biomedical materials research. Part A, 2026 · Design: other (preclinical formulation, distribution and efficacy study) · full text (PDF extraction) · open access: noPMID 42400341DOI 10.1002/jbm.a.70123Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentPolyethylene glycol 400 improves the bioavailability and anti-inflammatory activity of quercetin by modulating metabolic enzymes and efflux transporters.International journal of pharmaceutics, 2026 · Design: other (parallel two-group animal PK; in vitro mechanistic assays; mouse efficacy model) · full text (PDF extraction) · open access: noPMID 42595232DOI 10.1016/j.ijpharm.2026.127302Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentcRGD-Targeted Nanoparticles Co-Loaded with Ag, Quercetin and PD-L1 siRNA with Combined Antibacterial and Immunotherapeutic Functions Against Fusobacterium nucleatum-Associated Triple-Negative Breast Cancer.International journal of nanomedicine, 2026 · Design: other (parallel-group animal PK, tissue distribution; in vitro assays) · full text (PDF extraction) · open access: yesPMID 42732404DOI 10.2147/IJN.S616751 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentAn in Vivo Factor Connecting Sustained Reactive Oxygen Species Capture with Rapid Disposition: Quercetin Distribution into Hemoglobin.Biological & pharmaceutical bulletin, 2026 · Design: other (single-group IV PK plus in vitro and APAP-injury experiments) · full text (PDF extraction) · open access: noPMID 42802055DOI 10.1248/bpb.b26-00207Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentUlcerative colitis therapeutic effects and pharmacokinetics of flexible quercetin nanocrystals prepared with geniposide assistance.Frontiers in pharmacology, 2026 · Design: randomized parallel (two groups) · n: 12 rats (PK) · full text (PDF extraction) · open access: yes (free in PMC)PMID 42840060DOI 10.3389/fphar.2026.1873475 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentFormulation Development and Characterization of Quercetin Solid Dispersions with Integrated In Vitro Release and In Vivo Pharmacokinetic Assessment.Pharmaceuticals (Basel, Switzerland), 2026 · Design: randomized parallel (3 groups); plus in vitro experiments · n: 18 · full text (PDF extraction) · open access: yesPMID 42943322DOI 10.3390/ph19101625 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentImpact of calcium-reinforcement on stability, bioavailability, and bioactivity of quercetin-loaded zein/alginate-pectin nanoparticles.Journal of the science of food and agriculture, 2025 · Design: parallel (three groups); plus in vitro simulated digestion · full text (PDF extraction) · open access: noPMID 39394871DOI 10.1002/jsfa.13954Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentIntensification of quercetin nanobubble formulation and performance by multi-factor optimization and interaction analysis.Pharmaceutical development and technology, 2025 · Design: parallel (two groups) · full text (PDF extraction) · open access: noPMID 39718513DOI 10.1080/10837450.2024.2441182Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentSimultaneous ingestion of apple pectin enhances the absorption and antioxidant activity of quercetin in rats.Food science and biotechnology, 2025 · Design: parallel (diet groups) · full text (PDF extraction) · open access: yes (free in PMC)PMID 39758731DOI 10.1007/s10068-024-01657-2 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentTopical Anti-Inflammatory Effects of Quercetin Glycosides on Atopic Dermatitis-Like Lesions: Influence of the Glycone Type on Efficacy and Skin Absorption.Inflammation, 2025 · Design: other (in vitro permeation test plus cell and mouse efficacy) · full text (PDF extraction) · open access: yesPMID 39808370DOI 10.1007/s10753-025-02236-1 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentLight-activated photosensitizer/quercetin co-loaded extracellular vesicles for precise oral squamous cell carcinoma therapy.International journal of pharmaceutics, 2025 · Design: parallel (treatment groups) · full text (PDF extraction) · open access: noPMID 39824264DOI 10.1016/j.ijpharm.2025.125224Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentIron(III)-Quercetin Complex: In Vivo Acute Toxicity and Biodistribution of Novel MRI Agent.International journal of nanomedicine, 2025 · Design: other (preclinical PK, biodistribution and acute toxicity) · n: 32 rats · full text (PDF extraction) · open access: yesPMID 39906526DOI 10.2147/IJN.S496015 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentPreparation of PEG-modified isoquercitrin liposomes and anti-chronic kidney disease research.Journal of liposome research, 2025 · Design: parallel · n: 8 · full text (PDF extraction) · open access: noPMID 40125927DOI 10.1080/08982104.2025.2480782Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentNanoparticles of quercetin-gellan gum conjugate for the controlled delivery of fluconazole.Colloids and surfaces. B, Biointerfaces, 2025 · Design: parallel (two groups) · n: 12 · full text (PDF extraction) · open access: noPMID 40228425DOI 10.1016/j.colsurfb.2025.114681Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentZein and Trimethyl Chitosan-Based Core-Shell Nanoparticles for Quercetin Oral Delivery to Enhance Absorption by Paracellular Pathway in Obesity Mice.Biomaterials research, 2025 · Design: parallel · full text (PDF extraction) · open access: yesPMID 40296879DOI 10.34133/bmr.0193 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentDevelopment and Characterization of Chitosan Nanoparticles Containing Quercetin-β-Cyclodextrin Inclusion Complex for Improved Solubility, Brain Targeting, and Neuroprotective Potential Against Epilepsy.AAPS PharmSciTech, 2025 · Design: parallel · n: 12 (PK) · full text (PDF extraction) · open access: noPMID 40329128DOI 10.1208/s12249-025-03119-2Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentImproved antidiabetic potential of quercetin-loaded chitosan-lecithin nanoparticles for effective glycaemic control.Journal of drug targeting, 2025 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 40418582DOI 10.1080/1061186X.2025.2511837Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentEnhancing Oral Absorption of Quercetin Through Multifactorial Synergies in Crystal Dispersion Systems.Molecules (Basel, Switzerland), 2025 · Design: parallel (three formulation groups; sub-studies in vitro, Caco-2, SPIP) · full text (PDF extraction) · open access: yesPMID 40509277DOI 10.3390/molecules30112390 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentQuercetin-Loaded Ginkgo Starch Nanoparticles: A Promising Strategy to Improve Bioactive Delivery and Cellular Homeostasis in Functional Foods.Foods (Basel, Switzerland), 2025 · Design: parallel · full text (PDF extraction) · open access: yesPMID 40509418DOI 10.3390/foods14111890 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentSimultaneous estimation of donepezil and quercetin using ultra high performance liquid chromatography: pharmaceutical and pharmacokinetic applications in Alzheimer's disease.Bioanalysis, 2025 · Design: parallel (saline control group and treated group) · full text (PDF extraction) · open access: yes (free in PMC)PMID 40525309DOI 10.1080/17576180.2025.2518044 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentQuantification of gossypetin, myricetin, quercetin and isorhamnetin in mouse plasma: Pharmacokinetic profiling after oral administration of total flavone of Abelmoschi Corolla.Journal of pharmaceutical and biomedical analysis, 2025 · Design: parallel (each sampling time a separate group; single dose 3 dose levels and 7-day repeated) · full text (PDF extraction) · open access: noPMID 40544702DOI 10.1016/j.jpba.2025.117039Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentMolecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects.Frontiers in pharmacology, 2025 · Design: parallel · full text (PDF extraction) · open access: yesPMID 40552152DOI 10.3389/fphar.2025.1590688 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentUnveiling the photothermal mechanism and therapeutic potential of quercetin-loaded MXene-ZMOF@Chitosan in MCF-7 breast cancer.International journal of biological macromolecules, 2025 · Design: parallel · n: NR for PK · full text (PDF extraction) · open access: noPMID 40897275DOI 10.1016/j.ijbiomac.2025.147294Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentEnhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.Drug design, development and therapy, 2025 · Design: parallel · n: 12 · full text (PDF extraction) · open access: yesPMID 41084506DOI 10.2147/DDDT.S509270 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentQuercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies.AAPS PharmSciTech, 2024 · Design: parallel · full text (PDF extraction) · open access: noPMID 38316672DOI 10.1208/s12249-024-02736-7Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentEnhancing effect of the coexisting alpha-tocopherol on quercetin absorption and metabolism.Free radical research, 2024 · Design: parallel · full text (PDF extraction) · open access: noPMID 38330142DOI 10.1080/10715762.2024.2317206Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentSimple preparation and greatly improved oral bioavailability: The supersaturated drug delivery system of quercetin based on PVP K30.Drug delivery and translational research, 2024 · Design: parallel · full text (PDF extraction) · open access: noPMID 38421545DOI 10.1007/s13346-024-01544-7Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentLipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA.Life sciences, 2024 · Design: other (controlled animal efficacy study; in vitro release test) · n: 70 · full text (PDF extraction) · open access: noPMID 38462227DOI 10.1016/j.lfs.2024.122546Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentQuercetin nanocrystals for bioavailability enhancement: impact of different functional stabilizers on in vitro/in vivo drug performances.Pharmaceutical development and technology, 2024 · Design: parallel (6 groups) · n: 36 · full text (PDF extraction) · open access: noPMID 38808380DOI 10.1080/10837450.2024.2361654Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentFolic acid-conjugated long circulating co-encapsulated atorvastatin and quercetin solid lipid nanoparticles: pharmacokinetics and biodistribution in rats.Analytical methods : advancing methods and applications, 2024 · Design: parallel (three formulation groups) · n: 18 rats for PK; 30 rats for tissue distribution · full text (PDF extraction) · open access: noPMID 39314175DOI 10.1039/d4ay00821aVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentIsoquercitrin Loaded PEGylated Long Circulating Liposomes Improve Bone Mass and Reduce Oxidative Stress After Osteoporosis.AAPS PharmSciTech, 2024 · Design: parallel (two groups, PK) · full text (PDF extraction) · open access: noPMID 39638918DOI 10.1208/s12249-024-02993-6Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentEnhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson's disease.Frontiers in pharmacology, 2024 · Design: parallel (4 groups) · n: 24 · full text (PDF extraction) · open access: yesPMID 39931515DOI 10.3389/fphar.2024.1519649 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentRegional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co-administered with quercetin and paeoniflorin.Biopharmaceutics & drug disposition, 2023 · Design: parallel (2 groups) · n: 50 · full text (PDF extraction) · open access: noPMID 36638836DOI 10.1002/bdd.2346Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentUltrasonically Fabricated Beta-Carotene Nanoemulsion: Optimization, Characterization and Evaluation of Combinatorial Effect with Quercetin on Streptozotocin-Induced Diabetic Rat Model.Pharmaceutics, 2023 · Design: parallel · n: 12 · full text (PDF extraction) · open access: yesPMID 36839896DOI 10.3390/pharmaceutics15020574 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentInteraction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study.Toxicology mechanisms and methods, 2023 · Design: parallel (control vs quercetin-pretreated) · n: 12 · full text (PDF extraction) · open access: noPMID 36912048DOI 10.1080/15376516.2023.2188928Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentIn vitro outcomes of quercetin on Candida albicans planktonic and biofilm cells and in vivo effects on vulvovaginal candidiasis. Evidences of its mechanisms of action.Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023 · Design: parallel (4 groups) · n: 24 · full text (PDF extraction) · open access: noPMID 37043980DOI 10.1016/j.phymed.2023.154800Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentThe synergistic effect of epigallocatechin-3-gallate and quercetin co-loaded hydrogel beads on inflammatory bowel disease.Food & function, 2023 · Design: parallel · n: 30 · full text (PDF extraction) · open access: noPMID 37067270DOI 10.1039/d2fo04029hVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentSimultaneous Estimation of Quercetin and trans-Resveratrol in Cissus quadrangularis Extract in Rat Serum Using Validated LC-MS/MS Method: Application to Pharmacokinetic and Stability Studies.Molecules (Basel, Switzerland), 2023 · Design: single-arm · n: 6 · full text (PDF extraction) · open access: yesPMID 37375211DOI 10.3390/molecules28124656 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentZein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin.International journal of pharmaceutics, 2023 · Design: parallel · full text (PDF extraction) · open access: noPMID 37423375DOI 10.1016/j.ijpharm.2023.123216Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentTuning the Pharmacokinetic Performance of Quercetin by Cocrystallization.Crystal growth & design, 2023 · Design: other (parallel groups, single oral dose; plus in vitro dissolution) · full text (PDF extraction) · open access: yesPMID 37547881DOI 10.1021/acs.cgd.3c00590 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentThe Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation.Antioxidants (Basel, Switzerland), 2023 · Design: other (parallel groups; pharmacodynamic/hepatoprotection study with in vitro formulation characterization) · n: NR (four groups, n = 7 per group) · full text (PDF extraction) · open access: yesPMID 37627483DOI 10.3390/antiox12081487 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentComparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles.Pharmaceutics, 2023 · Design: other (parallel groups; sparse-sampling PK; oral vs intranasal) · full text (PDF extraction) · open access: yesPMID 37631250DOI 10.3390/pharmaceutics15082036 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentRole of Extracellular Vesicles in Absorption and Functional Mechanisms of Quercetin.Molecular nutrition & food research, 2023 · Design: other (single-dose rat experiment with vehicle control; in vitro cell experiments) · full text (PDF extraction) · open access: noPMID 37672798DOI 10.1002/mnfr.202300225Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentSelf-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats.International journal of pharmaceutics, 2022 · Design: parallel (rat PK, 6 groups); plus in vitro dissolution and Caco-2 permeability; plus separate 42-day diabetic rat pharmacodynamic study · n: 36 (PK) · full text (PDF extraction) · open access: noPMID 34813906DOI 10.1016/j.ijpharm.2021.121306Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentFabrication and Evaluation of Quercetin Nanoemulsion: A Delivery System with Improved Bioavailability and Therapeutic Efficacy in Diabetes Mellitus.Pharmaceuticals (Basel, Switzerland), 2022 · Design: parallel · n: 12 · full text (PDF extraction) · open access: yesPMID 35056127DOI 10.3390/ph15010070 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentProtective Effect of Quercetin 3-O-Glucuronide against Cisplatin Cytotoxicity in Renal Tubular Cells.Molecules (Basel, Switzerland), 2022 · Design: other (pilot comparison of oral vs intraperitoneal administration) · n: 2 · full text (PDF extraction) · open access: yesPMID 35209106DOI 10.3390/molecules27041319 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentDevelopment of Poly(lipoic acid) Nanoparticles with Improved Oral Bioavailability and Hepatoprotective Effects of Quercetin.Molecular pharmaceutics, 2022 · Design: parallel · full text (PDF extraction) · open access: noPMID 35353535DOI 10.1021/acs.molpharmaceut.2c00009Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- RodentTailoring of Selenium-Plated Novasomes for Fine-Tuning Pharmacokinetic and Tumor Uptake of Quercetin: In Vitro Optimization and In Vivo Radiobiodistribution Assessment in Ehrlich Tumor-Bearing Mice.Pharmaceutics, 2022 · Design: parallel · n: 72 (24 mice per group x 3 groups, as printed: 'three groups (24 mice per group)') · full text (PDF extraction) · open access: yesPMID 35456709DOI 10.3390/pharmaceutics14040875 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentFabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin.Pharmaceutics, 2022 · Design: parallel · n: 18 · full text (PDF extraction) · open access: yesPMID 35631483DOI 10.3390/pharmaceutics14050897 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentA novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury.Journal of nanobiotechnology, 2022 · Design: other (formulation and efficacy study with tissue distribution imaging) · full text (PDF extraction) · open access: yesPMID 35690763DOI 10.1186/s12951-022-01452-3 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentSurfactant-free amorphous solid dispersion with high dissolution for bioavailability enhancement of hydrophobic drugs: a case of quercetin.Drug development and industrial pharmacy, 2021 · Design: parallel (4 groups) plus in vitro dissolution · n: 24 rats · full text (PDF extraction) · open access: noPMID 33295808DOI 10.1080/03639045.2020.1862173Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentA Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity.International journal of molecular sciences, 2021 · Design: parallel · full text (PDF extraction) · open access: yesPMID 33450917DOI 10.3390/ijms22020729 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentRp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma.Molecules (Basel, Switzerland), 2021 · Design: parallel (3 groups: Q suspension, vehicle V, nano formula NQ) · full text (PDF extraction) · open access: yesPMID 33800848DOI 10.3390/molecules26051435 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- RodentThe contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin.Acta pharmaceutica Sinica. B, 2021 · Design: parallel (oral and IV groups, two particle sizes) · full text (PDF extraction) · open access: yesPMID 33996410DOI 10.1016/j.apsb.2021.02.015 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentCombination of α-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet.Journal of agricultural and food chemistry, 2021 · Design: parallel (5 diet groups) · n: 35 · full text (PDF extraction) · open access: noPMID 34008400DOI 10.1021/acs.jafc.1c01388Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentDietary Quercetin Reduces Plasma and Tissue Methylglyoxal and Advanced Glycation End Products in Healthy Mice Treated with Methylglyoxal.The Journal of nutrition, 2021 · Design: parallel · n: 15 (Exp 1); 50 (Exp 2) · full text (PDF extraction) · open access: noPMID 34091674DOI 10.1093/jn/nxab176Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentEnhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions.Drug delivery, 2021 · Design: parallel (randomly divided into six groups) · full text (PDF extraction) · open access: yesPMID 34142631DOI 10.1080/10717544.2021.1927244 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentEffect of Lipopolysaccharide-Induced Inflammatory Challenge on β-Glucuronidase Activity and the Concentration of Quercetin and Its Metabolites in the Choroid Plexus, Blood Plasma and Cerebrospinal Fluid.International journal of molecular sciences, 2021 · Design: other (repeated-measures within-animal: saline session then LPS session after 2 weeks recovery; in vitro cell experiments) · n: 40 ewes overall (Exp. 1 n=24; Exp. 2 n=16, 6 excluded from sampling) · full text (PDF extraction) · open access: yesPMID 34281178DOI 10.3390/ijms22137122 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentLipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin.International journal of pharmaceutics, 2021 · Design: other (formulation development, ex vivo permeation and pharmacodynamics) · full text (PDF extraction) · open access: noPMID 34563617DOI 10.1016/j.ijpharm.2021.121131Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentImproving gallic acid and quercetin bioavailability by polymeric nanoparticle formulation.Drug development and industrial pharmacy, 2021 · Design: parallel · full text (PDF extraction) · open access: noPMID 35179095DOI 10.1080/03639045.2022.2043353Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentWater-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats.European journal of nutrition, 2020 · Design: parallel · full text (PDF extraction) · open access: noPMID 31079173DOI 10.1007/s00394-019-01992-9Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentCharacterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use.Drug delivery and translational research, 2020 · Design: parallel · full text (PDF extraction) · open access: yesPMID 31482519DOI 10.1007/s13346-019-00674-7 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentA comparison of the absorption and metabolism of the major quercetin in brassica, quercetin-3-O-sophoroside, to that of quercetin aglycone, in rats.Food chemistry, 2020 · Design: parallel · full text (PDF extraction) · open access: noPMID 31771913DOI 10.1016/j.foodchem.2019.125880Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentQuercetin amorphous solid dispersions prepared by hot melt extrusion with enhanced solubility and intestinal absorption.Pharmaceutical development and technology, 2020 · Design: parallel · n: 30 · full text (PDF extraction) · open access: noPMID 31909684DOI 10.1080/10837450.2019.1709502Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentA new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020 · Design: parallel · n: 10 rats (PK) · full text (PDF extraction) · open access: noPMID 31945451DOI 10.1016/j.ejps.2020.105216Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentThe hydrogel of whey protein isolate coated by lotus root amylopectin enhance the stability and bioavailability of quercetin.Carbohydrate polymers, 2020 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 32172837DOI 10.1016/j.carbpol.2020.116009Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentQuercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats.Pharmaceutics, 2020 · Design: parallel (two groups) · n: 8 · full text (PDF extraction) · open access: yesPMID 32357395DOI 10.3390/pharmaceutics12050397 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentBrain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles.Drug delivery, 2020 · Design: parallel (free Que vs exosome-loaded Que) · full text (PDF extraction) · open access: yesPMID 32397764DOI 10.1080/10717544.2020.1762262 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentImpact of quercetin on pharmacokinetics of quetiapine: insights from in-vivo studies in wistar rats.Xenobiotica; the fate of foreign compounds in biological systems, 2020 · Design: parallel (4 groups) · n: 24 (4 groups of 6, as described) · full text (PDF extraction) · open access: noPMID 32623931DOI 10.1080/00498254.2020.1792002Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentPreparation of quercetin-nicotinamide cocrystals and their evaluation under in vivo and in vitro conditions.RSC advances, 2020 · Design: parallel · n: 10 · full text (PDF extraction) · open access: yesPMID 35516602DOI 10.1039/d0ra03324c (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentQuercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues.European journal of nutrition, 2019 · Design: parallel groups (quercetin vs DMSO control), several regimens · full text (PDF extraction) · open access: yesPMID 29594477DOI 10.1007/s00394-018-1680-7 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentCodelivery of Adriamycin and P-gp Inhibitor Quercetin Using PEGylated Liposomes to Overcome Cancer Drug Resistance.Journal of pharmaceutical sciences, 2019 · Design: parallel (5 groups) · n: 40 · full text (PDF extraction) · open access: noPMID 30610857DOI 10.1016/j.xphs.2018.12.016Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentQuercetin and its metabolite isorhamnetin promote glucose uptake through different signalling pathways in myotubes.Scientific reports, 2019 · Design: parallel (dose groups vs vehicle) · n: 20 · full text (PDF extraction) · open access: yesPMID 30804434DOI 10.1038/s41598-019-38711-7 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentPharmacokinetic comparison of quercetin, isoquercitrin, and quercetin-3-O-β-D-glucuronide in rats by HPLC-MS.PeerJ, 2019 · Design: parallel (three dose groups) · n: 15 · full text (PDF extraction) · open access: yesPMID 30941276DOI 10.7717/peerj.6665 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- RodentSimultaneous determination of curcumin, tetrahydrocurcumin, quercetin, and paeoniflorin by UHPLC-MS/MS in rat plasma and its application to a pharmacokinetic study.Journal of pharmaceutical and biomedical analysis, 2019 · Design: parallel · n: 10 · full text (PDF extraction) · open access: noPMID 31029801DOI 10.1016/j.jpba.2019.04.033Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentCholate-modified polymer-lipid hybrid nanoparticles for oral delivery of quercetin to potentiate the antileukemic effect.International journal of nanomedicine, 2019 · Design: parallel · full text (PDF extraction) · open access: yesPMID 31213814DOI 10.2147/IJN.S210057 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentCasein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin.International journal of pharmaceutics, 2019 · Design: parallel (randomized groups) · full text (PDF extraction) · open access: noPMID 31472219DOI 10.1016/j.ijpharm.2019.118652Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentEnhancing quercetin bioavailability by super paramagnetic starch-based hydrogel grafted with fumaric acid: An in vitro and in vivo study.Colloids and surfaces. B, Biointerfaces, 2019 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 31518957DOI 10.1016/j.colsurfb.2019.110487Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentPlasma quercetin metabolites are affected by intestinal microbiota of human microbiota-associated mice fed with a quercetin-containing diet.Journal of clinical biochemistry and nutrition, 2019 · Design: parallel · n: 20 · full text (PDF extraction) · open access: yesPMID 31777425DOI 10.3164/jcbn.19-45 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentA Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration.Oxidative medicine and cellular longevity, 2019 · Design: parallel · n: 18 (PK rats) · full text (PDF extraction) · open access: yesPMID 31781321DOI 10.1155/2019/1479571 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentEvaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models.Asian journal of pharmaceutical sciences, 2019 · Design: other (parallel groups, interaction study) · full text (PDF extraction) · open access: yesPMID 32104488DOI 10.1016/j.ajps.2018.12.003 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentA simple sensitive UFLC-MS/MS method for the simultaneous quantification of artesunate, dihydroartemisinin and quercetin in rat plasma and its application to pharmacokinetic studies.RSC advances, 2019 · Design: parallel · n: 12 · full text (PDF extraction) · open access: yesPMID 35541625DOI 10.1039/c9ra07707c (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentIntranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia.Artificial cells, nanomedicine, and biotechnology, 2018 · Design: parallel · n: 21 (PK/biodistribution, per Methods) · full text (PDF extraction) · open access: noPMID 28604104DOI 10.1080/21691401.2017.1337024Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentQuercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats.Xenobiotica; the fate of foreign compounds in biological systems, 2018 · Design: parallel · n: 18 (3 groups x 6 for in vivo PK; separate groups for sac study) · full text (PDF extraction) · open access: noPMID 28990837DOI 10.1080/00498254.2017.1390277Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentDetermination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 29153998DOI 10.1016/j.jchromb.2017.11.014Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentQuercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models.Food & function, 2018 · Design: other (in vitro Caco-2 transport + parallel-group rat PK) · n: 15 rats (3 groups) · full text (PDF extraction) · open access: noPMID 29168878DOI 10.1039/c7fo01576cVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentSimultaneous determination of kaempferol, quercetin, mangiferin, gallic acid, p-hydroxybenzoic acid and chlorpheniramine maleate in rat plasma after oral administration of Mang-Guo-Zhi-Ke tablets by UHPLC-MS/MS and its application to pharmacokinetics.Biomedical chromatography : BMC, 2018 · Design: single-arm · n: 6 · full text (PDF extraction) · open access: noPMID 29169211DOI 10.1002/bmc.4155Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentPreparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery.Bioscience, biotechnology, and biochemistry, 2018 · Design: parallel (two groups) · full text (PDF extraction) · open access: noPMID 29327653DOI 10.1080/09168451.2017.1419852Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentSimultaneous Quantification of Gallic Acid, Bergenin, Epicatechin, Epicatechin Gallate, Isoquercitrin, and Quercetin-3-Rhamnoside in Rat Plasma by LC-MS/MS Method and Its Application to Pharmacokinetics after Oral Administration of Ardisia japonica Extract.Evidence-based complementary and alternative medicine : eCAM, 2018 · Design: single-arm · n: 10 · full text (PDF extraction) · open access: yesPMID 29552082DOI 10.1155/2018/4964291 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentInfluence of long-term feeding of high-fat diet on quercetin and fat absorption from the small intestine in lymph duct-cannulated rats.Bioscience, biotechnology, and biochemistry, 2018 · Design: other (parallel-group rat lymph-cannulation study, 2 diets x 3 test emulsions) · full text (PDF extraction) · open access: noPMID 30032709DOI 10.1080/09168451.2018.1498726Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentUsing superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain.BMC pharmacology & toxicology, 2018 · Design: parallel · n: 42 · full text (PDF extraction) · open access: yesPMID 30253803DOI 10.1186/s40360-018-0249-7 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentDesign, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment.Artificial cells, nanomedicine, and biotechnology, 2018 · Design: parallel · n: 12 (PK) · full text (PDF extraction) · open access: noPMID 30322273DOI 10.1080/21691401.2018.1501379Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentLecithin-Stabilized Polymeric Micelles (L(sb)PMs) for Delivering Quercetin: Pharmacokinetic Studies and Therapeutic Effects of Quercetin Alone and in Combination with Doxorubicin.Scientific reports, 2018 · Design: parallel (separate groups by route and formulation) · n: 20 · full text (PDF extraction) · open access: yesPMID 30518853DOI 10.1038/s41598-018-36162-0 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- RodentA new validated HPLC method for the determination of quercetin: Application to study pharmacokinetics in rats.Biomedical chromatography : BMC, 2017 · Design: single-arm · n: 5 · full text (PDF extraction) · open access: noPMID 27555122DOI 10.1002/bmc.3819Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentZein nanoparticles for oral delivery of quercetin: Pharmacokinetic studies and preventive anti-inflammatory effects in a mouse model of endotoxemia.Nanomedicine : nanotechnology, biology, and medicine, 2017 · Design: parallel · n: 36 rats (6 groups x 6, from Table 3 n=6 per group) · full text (PDF extraction) · open access: noPMID 27615118DOI 10.1016/j.nano.2016.08.033Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentQuercetin-containing self-assemble proliposome preparation and evaluation.Journal of liposome research, 2017 · Design: other (animal in situ intestinal perfusion + parallel-group oral PK, random assignment) · n: 18 rats (PK); 9 rats (in situ, 3 groups of 3) · full text (PDF extraction) · open access: noPMID 27667265DOI 10.1080/08982104.2016.1239635Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentEffect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease.International journal of pharmaceutics, 2017 · Design: other (animal parallel-group chronic oral efficacy study with terminal brain level) · n: NR (4 groups of 8 animals per Methods) · full text (PDF extraction) · open access: noPMID 27915007DOI 10.1016/j.ijpharm.2016.11.061Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentEffects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction.European journal of drug metabolism and pharmacokinetics, 2017 · Design: other (parallel-group animal PK interaction study plus in vitro assays) · n: 36 (6 groups of 6) · full text (PDF extraction) · open access: noPMID 28070878DOI 10.1007/s13318-016-0393-7Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentEnhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting CYP3A4 and esterases.Pharmacological reports : PR, 2017 · Design: other (parallel-group animal PK interaction study plus in vitro assays) · n: 18 · full text (PDF extraction) · open access: noPMID 28189992DOI 10.1016/j.pharep.2016.12.002Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentSimultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC-UV.Evidence-based complementary and alternative medicine : eCAM, 2017 · Design: single-arm · n: 6 · full text (PDF extraction) · open access: yesPMID 28373891DOI 10.1155/2017/8370584 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentQuercetin and Green Tea Extract Supplementation Downregulates Genes Related to Tissue Inflammatory Responses to a 12-Week High Fat-Diet in Mice.Nutrients, 2017 · Design: parallel · n: 40 · full text (PDF extraction) · open access: yesPMID 28753942DOI 10.3390/nu9070773 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentAn UHPLC-MS/MS method for simultaneous determination of quercetin 3-O-rutinoside, kaempferol 3-O-rutinoside, isorhamnetin 3-O-rutinoside, bilobalide and ligustrazine in rat plasma, and its application to pharmacokinetic study of Xingxiong injection.Chinese journal of natural medicines, 2017 · Design: parallel · n: 18 · full text (PDF extraction) · open access: noPMID 28991533DOI 10.1016/S1875-5364(17)30101-2Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentPaclitaxel and quercetin nanoparticles co-loaded in microspheres to prolong retention time for pulmonary drug delivery.International journal of nanomedicine, 2017 · Design: parallel groups (animal PK) + in vitro release · full text (PDF extraction) · open access: yesPMID 29180863DOI 10.2147/IJN.S147028 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentPharmacokinetics of Quercetin-Loaded Methoxy Poly(ethylene glycol)-b-poly(L-lactic acid) Micelle after Oral Administration in Rats.BioMed research international, 2017 · Design: parallel (two groups) · n: 12 · full text (PDF extraction) · open access: yesPMID 29234675DOI 10.1155/2017/1750895 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentPharmacokinetics and antitumor efficacy of DSPE-PEG2000 polymeric liposomes loaded with quercetin and temozolomide: Analysis of their effectiveness in enhancing the chemosensitization of drug-resistant glioma cells.International journal of molecular medicine, 2016 · Design: other (in vitro release/cytotoxicity; randomized, in vivo biodistribution and plasma concentration in rats) · n: 108 rats (Methods) · full text (PDF extraction) · open access: yesPMID 26782731DOI 10.3892/ijmm.2016.2458 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentA rapid and sensitive LC-MS/MS method for quantification of quercetin-3-O-β-d-glucopyranosyl-7-O-β-d-gentiobioside in plasma and its application to a pharmacokinetic study.Biomedical chromatography : BMC, 2016 · Design: parallel (three dose groups) · n: 18 (3 groups of 6) · full text (PDF extraction) · open access: noPMID 26848536DOI 10.1002/bmc.3695Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentDevelopment and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study.International journal of nanomedicine, 2016 · Design: parallel (two formulations, IV) · n: 6 · full text (PDF extraction) · open access: yesPMID 27143878DOI 10.2147/IJN.S103681 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentSimultaneous Analysis of Quercetin and Naringenin in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study After Oral Administration.Journal of chromatographic science, 2016 · Design: single-arm · n: 6 · full text (PDF extraction) · open access: noPMID 27199443DOI 10.1093/chromsci/bmw079Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentDevelopment of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats.Fitoterapia, 2016 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 27431774DOI 10.1016/j.fitote.2016.07.008Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentImpact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats.Molecular medicine reports, 2016 · Design: other (specify): before-and-after (within-animal) design, day 1 CsA alone vs day 9 CsA + Que · n: 24 (Exp I); 24 (Exp II, 3 per group x 8 groups) · full text (PDF extraction) · open access: yesPMID 27510982DOI 10.3892/mmr.2016.5616 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentAbsorption and disposition of naringenin and quercetin after simultaneous administration via intestinal perfusion in mice.Food & function, 2016 · Design: other (specify): in situ single-pass intestinal perfusion; separate groups alone vs co-administered · full text (PDF extraction) · open access: noPMID 27515345DOI 10.1039/c6fo00633gVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentPromises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences.International journal of pharmaceutics, 2016 · Design: other (animal parallel-group single-dose oral PK; formulation comparison) · n: 12 (3 groups of 4) for PK · full text (PDF extraction) · open access: noPMID 27756627DOI 10.1016/j.ijpharm.2016.10.024Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentPharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS.Scientific reports, 2016 · Design: other (animal parallel-group oral PK plus IV tissue distribution) · n: 34 rats (10 oral PK, 24 IV tissue) · full text (PDF extraction) · open access: yesPMID 27775094DOI 10.1038/srep35460 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentMelibiose, a Nondigestible Disaccharide, Promotes Absorption of Quercetin Glycosides in Rat Small Intestine.Journal of agricultural and food chemistry, 2016 · Design: other (in situ ligated intestinal loop, parallel groups) plus in vitro mucosal homogenate hydrolysis · full text (PDF extraction) · open access: noPMID 27794607DOI 10.1021/acs.jafc.6b03714Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentComparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin.European journal of drug metabolism and pharmacokinetics, 2015 · Design: parallel (two groups) · n: 12 · full text (PDF extraction) · open access: noPMID 24888486DOI 10.1007/s13318-014-0206-9Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentFabrication, solid state characterization and bioavailability assessment of stable binary amorphous phases of Ritonavir with Quercetin.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2015 · Design: parallel · full text (PDF extraction) · open access: noPMID 25542681DOI 10.1016/j.ejpb.2014.12.025Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentPharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging.International journal of nanomedicine, 2015 · Design: parallel (four groups) · full text (PDF extraction) · open access: yesPMID 25945049DOI 10.2147/IJN.S78983 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentLC-ESI-MS/MS analysis of quercetin in rat plasma after oral administration of biodegradable nanoparticles.Biomedical chromatography : BMC, 2015 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 25973544DOI 10.1002/bmc.3486Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentPoly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats.International journal of nanomedicine, 2015 · Design: parallel (four groups, randomly allocated) · full text (PDF extraction) · open access: yesPMID 26089668DOI 10.2147/IJN.S80706 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentThe role of glycyrrhetinic acid modification on preparation and evaluation of quercetin-loaded chitosan-based self-aggregates.Journal of colloid and interface science, 2015 · Design: parallel (randomly divided into three groups) · n: 12 · full text (PDF extraction) · open access: noPMID 26319324DOI 10.1016/j.jcis.2015.08.049Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentFructooligosaccharide augments benefits of quercetin-3-O-β-glucoside on insulin sensitivity and plasma total cholesterol with promotion of flavonoid absorption in sucrose-fed rats.European journal of nutrition, 2014 · Design: parallel · n: 35 · full text (PDF extraction) · open access: noPMID 23784089DOI 10.1007/s00394-013-0546-2Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentCharacterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers.Colloids and surfaces. B, Biointerfaces, 2014 · Design: other (parallel, two randomized groups, tissue distribution) · full text (PDF extraction) · open access: noPMID 24333909DOI 10.1016/j.colsurfb.2013.11.029Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentPhytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L.Fitoterapia, 2014 · Design: parallel (4 groups) in rats, plus in vitro experiments · n: 24 rats (PK) · full text (PDF extraction) · open access: noPMID 24462958DOI 10.1016/j.fitote.2014.01.013Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentQuercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability.Journal of pharmaceutical sciences, 2014 · Design: parallel (two groups) in rats; plus in vitro Caco-2 and release studies · full text (PDF extraction) · open access: noPMID 24464737DOI 10.1002/jps.23858Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentA physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats.Biochemical pharmacology, 2014 · Design: other (PBK model development; in vitro S9 kinetic incubations) · full text (PDF extraction) · open access: noPMID 24561179DOI 10.1016/j.bcp.2014.02.007Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentOral administration of quercetin is unable to protect against isoproterenol cardiotoxicity.Naunyn-Schmiedeberg's archives of pharmacology, 2014 · Design: other (parallel groups; small PK sub-study) · n: 8 rats in PK study (3 + 3 quercetin, 2 control) · full text (PDF extraction) · open access: noPMID 24899384DOI 10.1007/s00210-014-0995-zVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentAmphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel.Biomaterials, 2014 · Design: other (parallel animal groups) · n: 25 · full text (PDF extraction) · open access: noPMID 24927684DOI 10.1016/j.biomaterials.2014.05.053Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentQuercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro.PloS one, 2014 · Design: other (animal in situ and gavage experiments plus in vitro cell experiments) · full text (PDF extraction) · open access: yesPMID 25058155DOI 10.1371/journal.pone.0102900 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentQuercetin declines plasma exposure of metoprolol tartrate in the rat model.Journal of advanced pharmaceutical technology & research, 2014 · Design: parallel · n: 12 · full text (PDF extraction) · open access: yesPMID 25364697DOI 10.4103/2231-4040.143038 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentHyaluronic acid-quercetin conjugate micelles: synthesis, characterization, in vitro and in vivo evaluation.Colloids and surfaces. B, Biointerfaces, 2014 · Design: parallel · full text (PDF extraction) · open access: noPMID 25454664DOI 10.1016/j.colsurfb.2014.10.025Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentEffects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L.Drug development and industrial pharmacy, 2013 · Design: parallel · n: 18 (PK) · full text (PDF extraction) · open access: noPMID 22757776DOI 10.3109/03639045.2012.699066Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentA novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine.Food chemistry, 2013 · Design: other (parallel groups, in situ ligated intestinal loop) · full text (PDF extraction) · open access: noPMID 23122060DOI 10.1016/j.foodchem.2012.08.028Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentInfluence of fatty acid patterns on the intestinal absorption pathway of quercetin in thoracic lymph duct-cannulated rats.The British journal of nutrition, 2013 · Design: parallel groups (3 treatments); in vivo lymph-cannulated rat · full text (PDF extraction) · open access: noPMID 23200408DOI 10.1017/S0007114512004564Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentA UPLC-MS/MS method for qualification of quercetin-3-O-β-D-glucopyranoside-(4→1)-α-L-rhamnoside in rat plasma and application to pharmacokinetic studies.Molecules (Basel, Switzerland), 2013 · Design: parallel · n: 6 · full text (PDF extraction) · open access: yesPMID 23470334DOI 10.3390/molecules18033050 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentNovel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity.Free radical biology & medicine, 2013 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 23792276DOI 10.1016/j.freeradbiomed.2013.05.041Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentPrenylation enhances quercetin uptake and reduces efflux in Caco-2 cells and enhances tissue accumulation in mice fed long-term.The Journal of nutrition, 2013 · Design: parallel · full text (PDF extraction) · open access: noPMID 23902958DOI 10.3945/jn.113.176818Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentCo-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity.Molecular pharmaceutics, 2013 · Design: parallel · n: 20 · full text (PDF extraction) · open access: noPMID 23927416DOI 10.1021/mp400311jVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentPharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method.Fitoterapia, 2012 · Design: parallel (three dose groups, random assignment) · n: 18 · full text (PDF extraction) · open access: noPMID 22056665DOI 10.1016/j.fitote.2011.10.012Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentThe increased cellular uptake and biliary excretion of curcumin by quercetin: a possible role of albumin binding interaction.Drug metabolism and disposition: the biological fate of chemicals, 2012 · Design: other (in vitro, ex vivo and parallel-group in vivo IV infusion study) · n: 21 (13 + 8, from Table 1) · full text (PDF extraction) · open access: noPMID 22584252DOI 10.1124/dmd.111.044123Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentSimultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of Oldenlandia diffusa extract in rats.Journal of chromatographic science, 2012 · Design: single-arm · n: 6 · full text (PDF extraction) · open access: noPMID 22718742DOI 10.1093/chromsci/bms086Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentPharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs.Archives of pharmacal research, 2012 · Design: rats: parallel, unpaired; dogs: crossover (7 d washout) · n: rats 20; dogs 6 · full text (PDF extraction) · open access: noPMID 23139136DOI 10.1007/s12272-012-1017-7Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentDevelopment of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model.Drug delivery and translational research, 2012 · Design: parallel · full text (PDF extraction) · open access: noPMID 25786720DOI 10.1007/s13346-012-0063-5Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentSystemic exposure of quercetin after administration of feng-liao-chang-wei-kang granules to rats.Journal of ethnopharmacology, 2011 · Design: single-arm · n: NR (abstract six; Methods three per group x two groups, inconsistent) · full text (PDF extraction) · open access: noPMID 20951785DOI 10.1016/j.jep.2010.10.014Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentPharmacokinetic profile of total quercetin after single oral dose of tartary buckwheat extracts in rats.Journal of agricultural and food chemistry, 2011 · Design: parallel (three dose groups, randomly assigned) · n: 18 · full text (PDF extraction) · open access: noPMID 21417279DOI 10.1021/jf1049529Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentQuercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4.Journal of agricultural and food chemistry, 2011 · Design: parallel (three groups, randomized); one week washout noted · n: 18 · full text (PDF extraction) · open access: noPMID 21466223DOI 10.1021/jf104786tVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentCocrystals of quercetin with improved solubility and oral bioavailability.Molecular pharmaceutics, 2011 · Design: parallel (n = 3 per group) · n: 15 · full text (PDF extraction) · open access: noPMID 21846121DOI 10.1021/mp200209jVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentLymphatic absorption of quercetin and rutin in rat and their pharmacokinetics in systemic plasma.Journal of agricultural and food chemistry, 2010 · Design: parallel (quercetin group and rutin group) · n: 12 · full text (PDF extraction) · open access: noPMID 19916501DOI 10.1021/jf9026124Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentQuercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts.Journal of agricultural and food chemistry, 2010 · Design: parallel (diet groups, animal study) plus in vitro cell time course · full text (PDF extraction) · open access: yes (free in PMC)PMID 20499918DOI 10.1021/jf101192k (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentComparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats.Fitoterapia, 2010 · Design: parallel (three groups, randomly divided) · n: 18 · full text (PDF extraction) · open access: noPMID 20603197DOI 10.1016/j.fitote.2010.06.028Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentDetermination of quercetin and resveratrol in whole blood--implications for bioavailability studies.Molecules (Basel, Switzerland), 2010 · Design: other (analytical method validation, in vitro spiking) · full text (PDF extraction) · open access: yesPMID 20877244DOI 10.3390/molecules15096570 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentEnhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.Journal of controlled release : official journal of the Controlled Release Society, 2009 · Design: other (parallel-group rat PK, formulation comparison; in situ perfusion absorption studies) · n: 10 rats for PK; 5 each for in situ groups · full text (PDF extraction) · open access: noPMID 18951932DOI 10.1016/j.jconrel.2008.10.002Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentDifferent profiles of quercetin metabolites in rat plasma: comparison of two administration methods.Bioscience, biotechnology, and biochemistry, 2009 · Design: other (parallel-group rat comparison of two administration methods; small human sample) · n: rats 6 per group; humans 4 · full text (PDF extraction) · open access: noPMID 19270373DOI 10.1271/bbb.80516Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentChronic ingestion of apple pectin can enhance the absorption of quercetin.Journal of agricultural and food chemistry, 2009 · Design: parallel (2x2 diet x compound) · n: 20 (PK groups); 12 (histology) · full text (PDF extraction) · open access: noPMID 19292474DOI 10.1021/jf803547hVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending8 verbatim quotes · view in JSON
- RodentFormulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded microemulsion.Colloids and surfaces. B, Biointerfaces, 2009 · Design: other (in situ intestinal perfusion, formulation comparison) · full text (PDF extraction) · open access: noPMID 19375897DOI 10.1016/j.colsurfb.2009.03.005Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentNondigestible saccharides suppress the bacterial degradation of quercetin aglycone in the large intestine and enhance the bioavailability of quercetin glucoside in rats.Journal of agricultural and food chemistry, 2009 · Design: parallel (E1 six diet groups); in vitro; in situ ligated segments · n: E1 48 (6 groups of 8); E2 3 groups; E3 12 rats (n=7 per group in Table 5) · full text (PDF extraction) · open access: noPMID 19807098DOI 10.1021/jf9024079Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentEnzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats.Biological & pharmaceutical bulletin, 2009 · Design: parallel · full text (PDF extraction) · open access: noPMID 19952424DOI 10.1248/bpb.32.2034Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentHPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum thunb. extract.Biomedical chromatography : BMC, 2008 · Design: single-arm · n: 5 (as printed in Fig. 3 and Table 2 captions) · full text (PDF extraction) · open access: noPMID 18059045DOI 10.1002/bmc.942Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentInfluence of dietary quercetin on glutathione redox status in mice.Journal of agricultural and food chemistry, 2008 · Design: parallel · n: 12 per group main study (5 diet groups incl. control); excretion subset n=2 per treatment group · full text (PDF extraction) · open access: noPMID 18198829DOI 10.1021/jf072358lVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentIntra-herb pharmacokinetics interaction between quercetin and isorhamentin.Acta pharmacologica Sinica, 2008 · Design: randomized crossover (Latin square, 3-way) plus in vitro cell transport · n: 12 rats · full text (PDF extraction) · open access: noPMID 18954533DOI 10.1111/j.1745-7254.2008.00884.xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- RodentBioavailability of [2-(14)C]quercetin-4'-glucoside in rats.Journal of agricultural and food chemistry, 2008 · Design: other (single-dose radiolabel mass-balance with serial sacrifice) · n: 18 (3 per each of 6 time points) · full text (PDF extraction) · open access: noPMID 19053221DOI 10.1021/jf802754sVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentQuantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin.Rapid communications in mass spectrometry : RCM, 2007 · Design: parallel (three dose groups, single oral dose) · n: 30 · full text (PDF extraction) · open access: noPMID 17154349DOI 10.1002/rcm.2814Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentEffect of pectin enhancement on plasma quercetin and fecal flora in rutin-supplemented mice.Journal of food science, 2007 · Design: parallel · n: 12 · full text (PDF extraction) · open access: noPMID 18034749DOI 10.1111/j.1750-3841.2007.00557.xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentRed wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro.British journal of pharmacology, 2006 · Design: other (in vitro/ex vivo cannulated everted jejunal sacs, paired comparison) · full text (PDF extraction) · open access: yes (free in PMC)PMID 16444288DOI 10.1038/sj.bjp.0706662 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- RodentThe flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro.Journal of agricultural and food chemistry, 2006 · Design: other (ex vivo Ussing chamber) · n: 16 mice · full text (PDF extraction) · open access: noPMID 16787048DOI 10.1021/jf0607922Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentAssociation between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma.Neoplasia (New York, N.Y.), 2005 · Design: other (animal PK sub-study within efficacy paper) · full text (PDF extraction) · open access: yes (free in PMC)PMID 15736313DOI 10.1593/neo.04337 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentBreast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.Molecular pharmacology, 2005 · Design: other (in situ perfusion; in vitro transport) · full text (PDF extraction) · open access: noPMID 15749994DOI 10.1124/mol.104.009753Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentDifference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005 · Design: other (animal PK; two oral dose groups plus higher HP dose) · full text (PDF extraction) · open access: noPMID 15760736DOI 10.1016/j.ejpb.2004.10.004Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentDisposition and metabolism of [2-14C]quercetin-4'-glucoside in rats.Drug metabolism and disposition: the biological fate of chemicals, 2005 · Design: other (animal radiolabel disposition study) · n: 12 · full text (PDF extraction) · open access: noPMID 15833931DOI 10.1124/dmd.104.002691Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentPharmacokinetics and modeling of quercetin and metabolites.Pharmaceutical research, 2005 · Design: other (animal PK; separate groups for iv, oral, intraportal; bile-cannulated and linked-rat experiments) · full text (PDF extraction) · open access: noPMID 15948033DOI 10.1007/s11095-005-4584-1Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentCo-administration of quercetin and catechin in rats alters their absorption but not their metabolism.Life sciences, 2005 · Design: parallel (3 diet groups, randomized) · full text (PDF extraction) · open access: noPMID 15979103DOI 10.1016/j.lfs.2005.03.033Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentAbsorption of quercetin and rutin in rat small intestine.Annals of nutrition & metabolism, 2005 · Design: other (animal in vivo trial + in vitro ligated loops) · full text (PDF extraction) · open access: noPMID 16006787DOI 10.1159/000086882Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentEnhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2004 · Design: parallel · full text (PDF extraction) · open access: noPMID 15018990DOI 10.1016/j.ejpb.2003.11.002Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentThe type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides.The British journal of nutrition, 2004 · Design: parallel · n: 31 · full text (PDF extraction) · open access: noPMID 15182387DOI 10.1079/BJN20041123Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- RodentIntestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase.The Journal of nutrition, 2003 · Design: other (in situ jejunum/ileum perfusion, parallel groups by inhibitor dose) · n: 20 rats (stated in Methods) · full text (PDF extraction) · open access: noPMID 12612151DOI 10.1093/jn/133.3.773Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- RodentProfound difference in pharmacokinetics between morin and its isomer quercetin in rats.The Journal of pharmacy and pharmacology, 2003 · Design: parallel (two oral doses) · full text (PDF extraction) · open access: noPMID 12631412DOI 10.1211/002235702487Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentAbsorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.Biochemical pharmacology, 2003 · Design: other (ex vivo everted sac, Latin-square randomised, inhibitor conditions) · n: 8 rats · full text (PDF extraction) · open access: noPMID 12663055DOI 10.1016/s0006-2952(03)00039-xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentAbsorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats.Journal of agricultural and food chemistry, 2003 · Design: parallel (four groups) · n: 16 · full text (PDF extraction) · open access: noPMID 12696973DOI 10.1021/jf026108aVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentDisposition of the flavonoid quercetin in rats after single intravenous and oral doses.Drug development and industrial pharmacy, 2003 · Design: parallel (IV, oral solution, oral suspension; sparse sampling, 6 rats per time point) · full text (PDF extraction) · open access: noPMID 12737533DOI 10.1081/ddc-120018375Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- RodentEnhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats.Bioscience, biotechnology, and biochemistry, 2003 · Design: parallel · n: 50 · full text (PDF extraction) · open access: noPMID 14730132DOI 10.1271/bbb.67.2548Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- RodentDetermination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-4'-glucoside.Journal of agricultural and food chemistry, 2002 · Design: single-arm · n: 3 · full text (PDF extraction) · open access: noPMID 12405795DOI 10.1021/jf020598pVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentIdentification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin.Free radical biology & medicine, 2001 · Design: other (single-dose metabolite identification in rats) · n: 30 · full text (PDF extraction) · open access: noPMID 11368925DOI 10.1016/s0891-5849(01)00522-6Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- RodentComparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats.The Journal of nutrition, 2001 · Design: other (in situ intestinal perfusion) · full text (PDF extraction) · open access: noPMID 11481403DOI 10.1093/jn/131.8.2109Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- RodentRespective bioavailability of quercetin aglycone and its glycosides in a rat model.BioFactors (Oxford, England), 2000 · Design: parallel groups, single experimental meal; two experiments · n: 24 (Exp 1) and 40 (Exp 2) · full text (PDF extraction) · open access: noPMID 11216481DOI 10.1002/biof.5520120127Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- RodentComparison of the bioavailability of quercetin and catechin in rats.Free radical biology & medicine, 1999 · Design: parallel groups (adapted 14 d vs non-adapted single meal), two experiments · n: NR (Exp 1: 24 rats per group; Exp 2: 8 per group, per Fig. 1) · full text (PDF extraction) · open access: noPMID 10641719DOI 10.1016/s0891-5849(99)00159-8Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- RodentBioavailability of rutin and quercetin in rats.FEBS letters, 1997 · Design: parallel · n: 90 · full text (PDF extraction) · open access: noPMID 9199494DOI 10.1016/s0014-5793(97)00467-5Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- Other animalHybrid nanogel system of quercetin-loaded squalene NLCs with zinc-HA network for dry eye syndrome.International journal of biological macromolecules, 2026 · Design: other (formulation comparison, within-animal contralateral eye comparison) · n: 15 · full text (PDF extraction) · open access: noPMID 41802516DOI 10.1016/j.ijbiomac.2026.151215Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- Other animalTargeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control.Translational vision science & technology, 2026 · Design: other (controlled animal efficacy study, 5 groups) · full text (PDF extraction) · open access: yesPMID 41944664DOI 10.1167/tvst.15.4.3 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- Other animalSafe and effective control of Mycoplasma gallisepticum: pharmacokinetic and residue profiling of doxycycline combined with quercetin nanomicelles.Veterinary research communications, 2026 · Design: parallel (PK sub-study in treated groups 3-7) · n: 420 chicks (7 groups x 3 replicates x 20 birds) · full text (PDF extraction) · open access: noPMID 42406229DOI 10.1007/s11259-026-11379-xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- Other animalQuercetin can serve as a CXR inhibitor to enhance florfenicol absorption by attenuating BCRP-mediated efflux in chickens.Poultry science, 2025 · Design: parallel · n: 40 for PK (120 allocated across experiments) · full text (PDF extraction) · open access: yesPMID 41066807DOI 10.1016/j.psj.2025.105893 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- Other animalPreparation of caffeic acid grafted chitosan self-assembled micelles to enhance oral bioavailability and antibacterial activity of quercetin.Frontiers in veterinary science, 2023 · Design: parallel · n: 12 · full text (PDF extraction) · open access: yes (free in PMC)PMID 37476826DOI 10.3389/fvets.2023.1218025 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- Other animalDevelopment of a UHPLC-MS/MS Method for the Determination of Quercetin in Milk and its Application to a Pharmacokinetic Study.Journal of veterinary research, 2019 · Design: single-arm · n: 9 · full text (PDF extraction) · open access: yesPMID 30989139DOI 10.2478/jvetres-2019-0013 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- Other animalBioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows.Journal of agricultural and food chemistry, 2018 · Design: randomized crossover · n: 3 · full text (PDF extraction) · open access: noPMID 30207714DOI 10.1021/acs.jafc.8b03049Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- Other animalQuercetin-loaded freeze-dried nanomicelles: Improving absorption and anti-glioma efficiency in vitro and in vivo.Journal of controlled release : official journal of the Controlled Release Society, 2016 · Design: other (specify): formulation comparison, in vitro and in vivo (mouse) · full text (PDF extraction) · open access: noPMID 27242199DOI 10.1016/j.jconrel.2016.05.045Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending10 verbatim quotes · view in JSON
- Other animalBioavailability of the flavonol quercetin in neonatal calves after oral administration of quercetin aglycone or rutin.Journal of dairy science, 2015 · Design: parallel (3 groups, repeated study on d 2 and d 29) · n: 21 · full text (PDF extraction) · open access: yesPMID 25795488DOI 10.3168/jds.2015-9361 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
- Other animalEnhancing oral bioavailability of quercetin using novel soluplus polymeric micelles.Nanoscale research letters, 2014 · Design: parallel (two groups of three dogs, randomly distributed) · n: 6 · full text (PDF extraction) · open access: yesPMID 26088982DOI 10.1186/1556-276X-9-684 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- Other animalEffects of quercetin and menadione on intestinal calcium absorption and the underlying mechanisms.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2013 · Design: other (controlled animal experiment, 4 groups: control, MEN, QT, MEN+QT) · full text (PDF extraction) · open access: noPMID 23000882DOI 10.1016/j.cbpa.2012.09.007Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- Other animalBioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration.Journal of dairy science, 2013 · Design: randomized crossover? (printed: crossover design, QA and RU in 3 equimolar doses in alternate order) · n: 6 · full text (PDF extraction) · open access: noPMID 23403185DOI 10.3168/jds.2012-6234Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- Other animalBioavailability of the flavonol quercetin in cows after intraruminal application of quercetin aglycone and rutin.Journal of dairy science, 2012 · Design: randomized crossover? (printed: crossover design with 2-d wash-out); i.v. trial in 2 animals · n: 5 · full text (PDF extraction) · open access: noPMID 22916908DOI 10.3168/jds.2012-5439Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- Other animalEffects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans.Food & function, 2011 · Design: other (in vivo model organism exposure study) · full text (PDF extraction) · open access: noPMID 21776484DOI 10.1039/c1fo10049aVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- Other animalOral bioavailability of quercetin from different quercetin glycosides in dogs.The British journal of nutrition, 2010 · Design: randomized crossover (Latin square for oral forms; oral vs i.v. crossover) · n: 9 (7 evaluated glycoside comparison; 8 absolute bioavailability) · full text (PDF extraction) · open access: noPMID 20230651DOI 10.1017/S000711451000053XVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- Other animalAbsorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens.Journal of the science of food and agriculture, 2010 · Design: parallel (randomly assigned cages, feeding experiment) · n: 240 hatched; 40 cages x 6 birds on day 21; two birds per cage on treatment · full text (PDF extraction) · open access: noPMID 20393998DOI 10.1002/jsfa.3944Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- Other animalEnhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits.International journal of pharmaceutics, 2005 · Design: parallel (groups of 8; control, co-administration, pretreatment, i.v.) · n: NR (eight groups of eight stated in Methods text; 'eight groups' listed as control + 3 co-admin + 3 pretreat + i.v.) · full text (PDF extraction) · open access: noPMID 15907592DOI 10.1016/j.ijpharm.2004.12.004Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- Other animalQuercetin significantly decreased cyclosporin oral bioavailability in pigs and rats.Life sciences, 2002 · Design: randomized crossover · n: pigs 6; rats 8 · full text (PDF extraction) · open access: noPMID 12427482DOI 10.1016/s0024-3205(02)02235-xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- Other animalOral absorption and metabolism of quercetin and sugar-conjugated derivatives in specific transport systems.Cancer letters, 1997 · Design: other (specify) · full text (PDF extraction) · open access: noPMID 9103284DOI 10.1016/s0304-3835(97)04655-7Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- In vitroNanoparticles for Synergistic Delivery of Curcumin and Quercetin Based on Zein and Sodium Caseinate: Preparation, Characterization, and Intestinal Absorption.Foods (Basel, Switzerland), 2026 · Design: other (in vitro experiments) · full text (PDF extraction) · open access: yesPMID 41596825DOI 10.3390/foods15020225 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroSpecies-specific deglucuronidation of quercetin glucuronides by the human gut microbiota.Bioscience, biotechnology, and biochemistry, 2026 · Design: other (in vitro enzymatic/whole-cell assay) · full text (PDF extraction) · open access: noPMID 41762160DOI 10.1093/bbb/zbag032Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroQuercetin-loaded exosomes derived from human umbilical cord mesenchymal stem cells alleviate microglia-mediated neuroinflammation via an anti-inflammatory mechanism.Inflammopharmacology, 2026 · Design: other (in vitro cell study) · full text (PDF extraction) · open access: yesPMID 42014646DOI 10.1007/s10787-026-02236-z (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroElucidating the self-assembly of prolamin-derived peptide nanoparticles prepared by enzymatic hydrolysis: implications for loading quercetin and intestinal absorption.Food chemistry, 2026 · Design: other (in vitro formulation study) · full text (PDF extraction) · open access: noPMID 42190375DOI 10.1016/j.foodchem.2026.149736Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroQuercetin loaded ZIF-8 coated human serum albumin nanoparticles relieve pulmonary fibrosis via NUAK1-YAP axis.Biomaterials advances, 2026 · Design: other (nanoparticle formulation and efficacy study) · full text (PDF extraction) · open access: noPMID 42284755DOI 10.1016/j.bioadv.2026.215002Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroPolyphenol combinations improve quercetin absorption and inhibit carbohydrate digestion while reducing glucose transport.Food & function, 2026 · Design: other (in vitro absorption/transport) · full text (PDF extraction) · open access: noPMID 42300428DOI 10.1039/d6fo00569aVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroDeamidated Zein Peptide Nanoparticles for Enhanced Quercetin Delivery: Structural Analysis, Stability, and Antioxidant Properties.Gels (Basel, Switzerland), 2026 · Design: other (in vitro formulation study) · full text (PDF extraction) · open access: yes (free in PMC)PMID 42354404DOI 10.3390/gels12060506 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroQuercetin Delivered by Mesenchymal Stem Cell-Derived Exosomes Improves Liver Fibrosis via the PI3K/Akt Signaling Pathway.ACS omega, 2026 · Design: other (preclinical formulation and efficacy study) · full text (PDF extraction) · open access: yesPMID 42395946DOI 10.1021/acsomega.6c03434 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroEnhancement of solubility and antioxidant activity of quercetin in choline-aspartate ionic liquid: spectroscopic, volumetric and kinetic insights.BMC chemistry, 2026 · Design: other (in vitro physicochemical) · full text (PDF extraction) · open access: yesPMID 42443946DOI 10.1186/s13065-026-01883-1 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroPorous-starch-encapsulated quercetin remodels the gut microbiota and elevates short-chain fatty acids, alleviating hyperglycaemia-associated phenotypes in T2DM mice.Frontiers in nutrition, 2026 · Design: other (in vitro release test plus mouse efficacy study) · full text (PDF extraction) · open access: yesPMID 42781481DOI 10.3389/fnut.2026.1851659 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroEngineering Quercetin-Loaded Nanostructured Lipid Carriers for Enhanced Oral Delivery: Physicochemical Characterization and In Vitro Antioxidant Evaluation.Assay and drug development technologies, 2026 · Design: other (in vitro formulation characterization) · full text (PDF extraction) · open access: noPMID 42960614DOI 10.1177/1540658X261502041Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroAn in vitro investigation on the physicochemical properties of different quercetin formulations.Journal of complementary & integrative medicine, 2025 · Design: other (in vitro formulation comparison) · full text (PDF extraction) · open access: noPMID 39665312DOI 10.1515/jcim-2024-2002Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- In vitroElectronic structures of isoquercitrin and its pharmacokinetic exploration with Dengue virus 1 NS5 methyl transferase.Cellular and molecular biology (Noisy-le-Grand, France), 2025 · Design: other (computational: DFT, ADMET prediction, molecular docking) · full text (PDF extraction) · open access: noPMID 39976905DOI 10.14715/cmb/2025.71.2.16Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroQuercetin loaded biogenic squalene nano-lipid carriers for the treatment of dry eye syndrome.International journal of pharmaceutics, 2025 · Design: other (preclinical formulation comparison; within-animal comparison, NLC right eye vs solution left eye) · n: 12 rabbits (all in vivo studies) · full text (PDF extraction) · open access: noPMID 40074160DOI 10.1016/j.ijpharm.2025.125457Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroPharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives.Chemistry & biodiversity, 2025 · Design: other (in silico prediction + in vitro cytotoxicity) · full text (PDF extraction) · open access: yesPMID 40345208DOI 10.1002/cbdv.202500119 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroQuercetin-3-β-aminobutyrate (HPS-β) as a promising novel anti-inflammatory agent for the treatment of sepsis.Bioorganic chemistry, 2025 · Design: other (in vitro solubility measurement; mouse efficacy study) · full text (PDF extraction) · open access: noPMID 40505320DOI 10.1016/j.bioorg.2025.108642Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroEnhancing the encapsulation efficiency, bioavailability, and antioxidant efficacy of quercetin and maize peptide by a novel multi-frequency pulsed ultrasonic-assisted nanoliposomal encapsulation system.Food research international (Ottawa, Ont.), 2025 · Design: other (specify): in vitro formulation study · full text (PDF extraction) · open access: noPMID 40790677DOI 10.1016/j.foodres.2025.116874Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroSodium alginate-mediated interfacial structuring in soy protein-quercetin composite emulsions: A synergistic strategy for encapsulation and bioavailability enhancement of lipophilic bioactives.Food chemistry, 2025 · Design: other (specify): in vitro formulation study · full text (PDF extraction) · open access: noPMID 40795549DOI 10.1016/j.foodchem.2025.145812Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroImproving the properties of whey protein isolate-zein nanogels with novel acidifiers: Re-dispersity, stability and quercetin bioavailability.International journal of biological macromolecules, 2024 · Design: other (in vitro formulation study) · full text (PDF extraction) · open access: noPMID 38569984DOI 10.1016/j.ijbiomac.2024.131284Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroIntranasal Delivery of Carvedilol- and Quercetin-Encapsulated Cationic Nanoliposomes for Cardiovascular Targeting: Formulation and In Vitro and Ex Vivo Studies.ACS applied bio materials, 2024 · Design: other (in vitro / ex vivo formulation study) · full text (PDF extraction) · open access: yesPMID 38581388DOI 10.1021/acsabm.4c00102 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroEffect of ultrasonic power on delivery of quercetin in emulsions stabilized using octenyl succinic anhydride (OSA) modified broken japonica rice starch.International journal of biological macromolecules, 2024 · Design: other (in vitro formulation study) · full text (PDF extraction) · open access: noPMID 38614171DOI 10.1016/j.ijbiomac.2024.131557Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroTea saponin-Zein binary complex as a quercetin delivery vehicle: preparation, characterization, and functional evaluation.International journal of biological macromolecules, 2024 · Design: other (in vitro formulation and simulated digestion study) · full text (PDF extraction) · open access: noPMID 39255893DOI 10.1016/j.ijbiomac.2024.135485Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroEffective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and β-catenin signaling pathway in triple-negative breast cancer.Biochemical and biophysical research communications, 2023 · Design: other (in vitro) · full text (PDF extraction) · open access: noPMID 37141640DOI 10.1016/j.bbrc.2023.03.077Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroNovel Hybrid Inulin-Soy Protein Nanoparticles Simultaneously Loaded with (-)-Epicatechin and Quercetin and Their In Vitro Evaluation.Nanomaterials (Basel, Switzerland), 2023 · Design: other (in vitro) · full text (PDF extraction) · open access: yesPMID 37242034DOI 10.3390/nano13101615 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroQuercetin Enhances the Availability of 5-Heptadecylresorcinol by Inhibiting the Expression of P-gp.Journal of agricultural and food chemistry, 2023 · Design: other (in vitro Caco-2 transport plus parallel single-dose mouse groups) · full text (PDF extraction) · open access: noPMID 37962857DOI 10.1021/acs.jafc.3c05518Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroHydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells.International journal of molecular sciences, 2023 · Design: other (in vitro cell culture) · full text (PDF extraction) · open access: yesPMID 38068974DOI 10.3390/ijms242316652 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroFormulation, Solubilization, and In Vitro Characterization of Quercetin-Incorporated Mixed Micelles of PEO-PPO-PEO Block Copolymers.Applied biochemistry and biotechnology, 2022 · Design: other (in vitro formulation characterization) · full text (PDF extraction) · open access: noPMID 34611857DOI 10.1007/s12010-021-03691-wVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroCo-encapsulation of (-)-epigallocatechin-3-gallate and quercetin in double emulsion hydrogel beads: Microstructures, functional properties, and digestion behaviors.Food chemistry, 2022 · Design: other (in vitro simulated gastric + small-intestinal digestion, triplicate) · full text (PDF extraction) · open access: noPMID 34710677DOI 10.1016/j.foodchem.2021.131427Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroEncapsulating quercetin in cyclodextrin metal-organic frameworks improved its solubility and bioavailability.Journal of the science of food and agriculture, 2022 · Design: other (in vitro physicochemical characterisation and solubility) · full text (PDF extraction) · open access: noPMID 34952968DOI 10.1002/jsfa.11738Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroHohenbuehelia serotina polysaccharides self-assembled nanoparticles for delivery of quercetin and their anti-proliferative activities during gastrointestinal digestion in vitro.International journal of biological macromolecules, 2022 · Design: other (in vitro simulated oral-gastric-intestinal digestion) · full text (PDF extraction) · open access: noPMID 35093441DOI 10.1016/j.ijbiomac.2022.01.143Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroEnhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate.Journal of food science, 2022 · Design: other (in vitro solubility and Caco-2 permeability) · full text (PDF extraction) · open access: noPMID 35122241DOI 10.1111/1750-3841.16049Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroTargeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment.Drug delivery, 2022 · Design: other (in vitro release; cell and xenograft efficacy not extracted) · full text (PDF extraction) · open access: yesPMID 35343862DOI 10.1080/10717544.2022.2055225 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroThe nanomicelles consisting of lotus root amylopectin and quinoa protein: Construction and encapsulation for quercetin.Food chemistry, 2022 · Design: other (in vitro formulation characterization and simulated GI digestion) · full text (PDF extraction) · open access: noPMID 35429932DOI 10.1016/j.foodchem.2022.132924Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroDesign of a new light curable starch-based hydrogel drug delivery system to improve the release rate of quercetin as a poorly water-soluble drug.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2022 · Design: other (in vitro release study of hydrogel formulations) · full text (PDF extraction) · open access: noPMID 35430382DOI 10.1016/j.ejps.2022.106191Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroA Comparative Study of Quercetin-Loaded Nanocochleates and Liposomes: Formulation, Characterization, Assessment of Degradation and In Vitro Anticancer Potential.Pharmaceutics, 2022 · Design: other (formulation development and in vitro characterization) · full text (PDF extraction) · open access: yesPMID 36015227DOI 10.3390/pharmaceutics14081601 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroO-Sulfation disposition of curcumin and quercetin in SULT1A3 overexpressing HEK293 cells: the role of arylsulfatase B in cellular O-sulfation regulated by transporters.Food & function, 2022 · Design: other (in vitro metabolism/transport study) · full text (PDF extraction) · open access: noPMID 36156668DOI 10.1039/d2fo01436jVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroBioavailability of quercetin in zein-based colloidal particles-stabilized Pickering emulsions investigated by the in vitro digestion coupled with Caco-2 cell monolayer model.Food chemistry, 2021 · Design: other (in vitro digestion/Caco-2) · full text (PDF extraction) · open access: noPMID 34034052DOI 10.1016/j.foodchem.2021.130152Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroEffects of quercetin and artemetin prenylation on bioavailability and bioactivity.Chemistry and physics of lipids, 2021 · Design: other (in vitro cell culture) · full text (PDF extraction) · open access: noPMID 34529978DOI 10.1016/j.chemphyslip.2021.105137Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroChanges in the Content and Bioavailability of Onion Quercetin and Grape Resveratrol During In Vitro Human Digestion.Foods (Basel, Switzerland), 2020 · Design: other (in vitro digestion, triplicate) · full text (PDF extraction) · open access: yesPMID 32481545DOI 10.3390/foods9060694 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroThe Human Microbial Metabolism of Quercetin in Different Formulations: An In Vitro Evaluation.Foods (Basel, Switzerland), 2020 · Design: other (in vitro fermentation, triplicate) · n: 3 fecal donors pooled · full text (PDF extraction) · open access: yesPMID 32823976DOI 10.3390/foods9081121 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroInjectable Quercetin-Loaded Hydrogel with Cartilage-Protection and Immunomodulatory Properties for Articular Cartilage Repair.ACS applied bio materials, 2020 · Design: other (in vitro release from hydrogel; efficacy in rat osteochondral defect model not extracted) · full text (PDF extraction) · open access: noPMID 35019280DOI 10.1021/acsabm.9b00673Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroIn vitro bioaccessibility and bioavailability of quercetin from the quercetin-fortified bread products with reduced glycemic potential.Food chemistry, 2019 · Design: other (in vitro static digestion with dialysis) · full text (PDF extraction) · open access: noPMID 30827656DOI 10.1016/j.foodchem.2019.01.199Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroBacteroides thetaiotaomicron Starch Utilization Promotes Quercetin Degradation and Butyrate Production by Eubacterium ramulus.Frontiers in microbiology, 2019 · Design: other (in vitro mono- and co-culture) · full text (PDF extraction) · open access: yesPMID 31191482DOI 10.3389/fmicb.2019.01145 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroMucoadhesive Chitosan-Gum Arabic Nanoparticles Enhance the Absorption and Antioxidant Activity of Quercetin in the Intestinal Cellular Environment.Journal of agricultural and food chemistry, 2019 · Design: parallel · n: 36 rats (6 groups of 6, as printed in Methods) · full text (PDF extraction) · open access: noPMID 31314514DOI 10.1021/acs.jafc.9b00008Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroPreparation and Characterization of Quercetin-Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability.Journal of food science, 2019 · Design: other (in vitro formulation comparison) · full text (PDF extraction) · open access: noPMID 31553062DOI 10.1111/1750-3841.14803Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroNovel biodegradable and non-fouling systems for controlled-release based on poly(ε-caprolactone)/Quercetin blends and biomimetic bacterial S-layer coatings.RSC advances, 2019 · Design: other (in vitro release study) · full text (PDF extraction) · open access: yesPMID 35527860DOI 10.1039/c9ra04398e (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroUse of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken.Scientific reports, 2018 · Design: parallel groups (3 groups per experiment) · n: 15 (enrofloxacin PK); 18 (Rho123 perfusion) · full text (PDF extraction) · open access: yesPMID 29535328DOI 10.1038/s41598-018-22354-1 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroCuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo-Photothermal Therapy.ACS applied materials & interfaces, 2018 · Design: other (formulation development with in vitro and mouse tumor-model experiments) · full text (PDF extraction) · open access: noPMID 30215253DOI 10.1021/acsami.8b13487Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroQuercetin nanoparticles with enhanced bioavailability as multifunctional agents toward amyloid induced neurotoxicity.Journal of materials chemistry. B, 2018 · Design: other (in vitro) · full text (PDF extraction) · open access: noPMID 32254423DOI 10.1039/c7tb03053cVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroNovel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro.Carbohydrate polymers, 2017 · Design: other (in vitro formulation comparison) · full text (PDF extraction) · open access: noPMID 27988001DOI 10.1016/j.carbpol.2016.09.067Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroTowards an Understanding of the Low Bioavailability of Quercetin: A Study of Its Interaction with Intestinal Lipids.Nutrients, 2017 · Design: other (in vitro) · full text (PDF extraction) · open access: yesPMID 28165426DOI 10.3390/nu9020111 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending4 verbatim quotes · view in JSON
- In vitroFurther exploring the absorption and enterocyte metabolism of quercetin forms in the Caco-2 model using nano-LC-TOF-MS.Electrophoresis, 2016 · Design: other (in vitro Caco-2 transport assay) · full text (PDF extraction) · open access: noPMID 26542615DOI 10.1002/elps.201500375Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroLipid-based nanocarrier for quercetin delivery: system characterization and molecular interactions studies.Drug development and industrial pharmacy, 2016 · Design: other (in vitro formulation and release study) · full text (PDF extraction) · open access: noPMID 26571009DOI 10.3109/03639045.2015.1118491Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroQuercetin derivatives as novel antihypertensive agents: Synthesis and physiological characterization.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016 · Design: other (in vitro digestion test; ex vivo and in vivo pharmacology) · full text (PDF extraction) · open access: noPMID 26631584DOI 10.1016/j.ejps.2015.11.021Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroEsterification of Quercetin Increases Its Transport Across Human Caco-2 Cells.Journal of food science, 2016 · Design: other (specify): in vitro transport · full text (PDF extraction) · open access: noPMID 27301074DOI 10.1111/1750-3841.13366Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroCharacterisation of water-soluble proanthocyanidins of Pyracantha fortuneana fruit and their improvement in cell bioavailable antioxidant activity of quercetin.Food chemistry, 2015 · Design: other (in vitro) · full text (PDF extraction) · open access: noPMID 25236255DOI 10.1016/j.foodchem.2014.07.091Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroDual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges.Journal of controlled release : official journal of the Controlled Release Society, 2015 · Design: other (in vitro formulation characterization) · full text (PDF extraction) · open access: noPMID 26344396DOI 10.1016/j.jconrel.2015.08.052Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroUse of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites.Biochemical pharmacology, 2015 · Design: other (PBK modelling with in vitro kinetics) · n: 20 individual human liver S9 donors · full text (PDF extraction) · open access: noPMID 26441251DOI 10.1016/j.bcp.2015.09.022Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- In vitroQuercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.Food & function, 2012 · Design: other (in vitro cell experiments plus 2-week parallel-group mouse study) · n: NR (mice: 4 groups of 5) · full text (PDF extraction) · open access: yes (free in PMC)PMID 22438067DOI 10.1039/c2fo10254d (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroAnti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: the relationships to chemical structures.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012 · Design: other (in vitro skin permeation, in vitro neutrophil assays, 5-day in vivo nude mouse skin irritation) · n: n=4 skin samples per permeant · full text (PDF extraction) · open access: noPMID 22609526DOI 10.1016/j.ejps.2012.04.024Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroThe bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux.Drug metabolism and disposition: the biological fate of chemicals, 2011 · Design: other (in vitro bidirectional transport) · full text (PDF extraction) · open access: noPMID 21139040DOI 10.1124/dmd.110.035212Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending2 verbatim quotes · view in JSON
- In vitroColon-targeted quercetin delivery using natural polymer to enhance its bioavailability.Pharmacognosy research, 2011 · Design: other (in vitro formulation/dissolution study) · full text (PDF extraction) · open access: yesPMID 21731393DOI 10.4103/0974-8490.79113 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroThe kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes.The Journal of nutritional biochemistry, 2010 · Design: other (in vitro enzyme kinetics, pooled and individual microsomes) · n: 15 rats · full text (PDF extraction) · open access: yes (free in PMC)PMID 19446449DOI 10.1016/j.jnutbio.2009.02.006 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- In vitroIn vitro solubility, stability and permeability of novel quercetin-amino acid conjugates.Bioorganic & medicinal chemistry, 2009 · Design: other (in vitro characterization) · full text (PDF extraction) · open access: noPMID 19128975DOI 10.1016/j.bmc.2008.12.043Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroQuercetin and naringenin transport across human intestinal Caco-2 cells.The Journal of pharmacy and pharmacology, 2009 · Design: other (in vitro transport) · full text (PDF extraction) · open access: noPMID 19903372DOI 10.1211/jpp/61.11.0006Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- In vitroIn vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity.International journal of pharmaceutics, 2007 · Design: other (in vitro release, permeation and skin retention) · full text (PDF extraction) · open access: noPMID 16959452DOI 10.1016/j.ijpharm.2006.08.006Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroEster-based precursors to increase the bioavailability of quercetin.Journal of medicinal chemistry, 2007 · Design: other (in vitro transepithelial transport) · n: 223 individual transport experiments in total (Results 2.4) · full text (PDF extraction) · open access: noPMID 17228866DOI 10.1021/jm060912xVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending3 verbatim quotes · view in JSON
- In vitroIn vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer.Nutrition journal, 2005 · Design: other (in vitro digestion/Caco-2 uptake) · full text (PDF extraction) · open access: yesPMID 15644141DOI 10.1186/1475-2891-4-1 (free full text)Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending5 verbatim quotes · view in JSON
- In vitroThe effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin.Archives of pharmacal research, 2004 · Design: other (in vitro permeation/release study) · full text (PDF extraction) · open access: noPMID 15357005DOI 10.1007/BF02980146Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending7 verbatim quotes · view in JSON
- In vitroUptake of quercetin and quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers.Journal of agricultural and food chemistry, 2004 · Design: other (in vitro cell uptake) · full text (PDF extraction) · open access: noPMID 15537334DOI 10.1021/jf030733dVerification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending9 verbatim quotes · view in JSON
- In vitroMetabolism of quercetin and kaempferol by rat hepatocytes and the identification of flavonoid glycosides in human plasma.Xenobiotica; the fate of foreign compounds in biological systems, 2002 · Design: other (in vitro incubation; small human uncontrolled single-group exposure) · n: 4 (human volunteers); 4 hepatocyte determinations · full text (PDF extraction) · open access: noPMID 12028662DOI 10.1080/00498250110107886Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending1 verbatim quote · view in JSON
- In vitroCellular uptake of dietary flavonoid quercetin 4'-beta-glucoside by sodium-dependent glucose transporter SGLT1.The Journal of pharmacology and experimental therapeutics, 2000 · Design: in vitro uptake experiments · full text (PDF extraction) · open access: noPMID 10945831Verification: values extracted verbatim from the full-text PDF (bundle 2, 2026-11-02); reviewer check pending6 verbatim quotes · view in JSON
Reviewer
PhD, molecular pathology (UAB); BS, molecular biology & biochemistry (St. Olaf College). Reviews the science and evidence (not medical advice).
Draft, pending sign-off Next review: set at sign-off
Animal and lab findings are labeled and never presented as proof of effects in people. Claims are limited to what the cited studies report. See our methodology.